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    Risk factors for pancreatic cancer mortality: Extended follow-up of the original whitehall study

    Access Status
    Open access via publisher
    Authors
    Batty, G.
    Kivimaki, M.
    Morrison, D.
    Huxley, Rachel
    Smith, G.
    Clarke, R.
    Marmot, M.
    Shipley, M.
    Date
    2009
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Batty, G. and Kivimaki, M. and Morrison, D. and Huxley, R. and Smith, G. and Clarke, R. and Marmot, M. et al. 2009. Risk factors for pancreatic cancer mortality: Extended follow-up of the original whitehall study. Cancer Epidemiology Biomarkers and Prevention. 18 (2): pp. 673-675.
    Source Title
    Cancer Epidemiology Biomarkers and Prevention
    DOI
    10.1158/1055-9965.EPI-08-1032
    ISSN
    1055-9965
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/22866
    Collection
    • Curtin Research Publications
    Abstract

    Given the well-established links between diabetes and elevated rates of pancreatic cancer, there are reasons to anticipate that other markers of metabolic abnormality (increased body mass index, plasma cholesterol, and blood pressure) and their correlates (physical activity and socioeconomic status) may also confer increased risk. However, to date, the results of a series of population-based cohort studies are inconclusive. We examined these associations in the original Whitehall cohort study of 17,898 men. A maximum of 38 years of follow-up gave rise to 163 deaths due to carcinoma of the pancreas. Although Poisson regression analyses confirmed established risk factor-disease associations for increasingage, smoking, and type II diabetes, there was essentially no evidence that body mass index (rate ratio, 1.01; 95% confidence interval per 1 SD increase, 0.86-1.18), plasma cholesterol (0.91; 0.78-1.07), diastolic blood pressure (0.93; 0.78-1.09), systolic blood pressure (0.98; 0.83-1.15), physical activity (sedentary versus high: 1.37; 0.89-2.12), or socioeconomic status [clerical (low) versus professional/executive, 0.95; 0.59-1.51] offered any predictive value for pancreatic cancer mortality. These results were unchanged following control for a range of covariates. Copyright © 2009 American Association for Cancer Research.

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