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    Arterial retention of apolipoprotein B48- and B100- containing lipoproteins in atherogenesis

    Access Status
    Fulltext not available
    Authors
    Proctor, Spencer
    Vine, Donna
    Mamo, John
    Date
    2002
    Type
    Journal Article
    
    Metadata
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    Citation
    Proctor, Spencer and Vine, Donna and Mamo, John. 2002. Arterial retention of apolipoprotein B48- and B100- containing lipoproteins in atherogenesis. Current Opinion in Lipidology 13 (5): pp. 461-470.
    Source Title
    Current Opinion in Lipidology
    ISSN
    09579672
    Faculty
    Faculty of Health Sciences
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/23067
    Collection
    • Curtin Research Publications
    Abstract

    Purpose of review: The ‘response to retention’ hypothesis of atherosclerosis suggests that the arterial deposition of cholesterol is directly proportional to the concentration of circulating plasma lipoproteins. However, there is increasing evidence to support the concept that specific lipoproteins may be preferentially retained within the arterial wall, possibly as a result of greater affinity for cell surface and extracellular matrices. Recent findings: Recently, key studies have provided insight into mechanisms involved in the interaction of apolipoprotein B (apoB)-containing lipoproteins with extracellular matrices. In addition, novel methods and innovative experimental design has enabled us to differentiate between the delivery, retention and efflux of apoB48- and apoB100-containing lipoproteins. Other studies have demonstrated a relationship between extracellular matrix proteoglycan expression and the development of atherosclerosis in vivo. Discussion in the present review also extends to the mechanisms that are involved in the relative intimal retention of apoB48- and apoB100-containing lipoproteins in order to explain the atherogenicity of these macromolecules. Summary: The perspective of this review is to highlight recent advances in the area of arterial lipoprotein retention and the physiological significance these processes may have in the aetiology of cardiovascular disease. Importantly, an understanding of the mechanisms responsible for the retention of apoB48/B100-containing lipoproteins will enable new strategies to be developed for the future management of cardiovascular disease.

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