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    Hypertension, antihypertensive treatment and cancer incidence and mortality: A pooled collaborative analysis of 12 Australian and New Zealand cohorts

    Access Status
    Open access via publisher
    Authors
    Harding, J.
    Sooriyakumaran, M.
    Anstey, K.
    Adams, R.
    Balkau, B.
    Brennan-Olsen, S.
    Briffa, T.
    Davis, T.
    Davis, W.
    Dobson, A.
    Giles, G.
    Grant, J.
    Huxley, Rachel
    Knuiman, M.
    Luszcz, M.
    Mitchell, P.
    Pasco, J.
    Reid, C.
    Simmons, D.
    Simons, L.
    Taylor, A.
    Tonkin, A.
    Woodward, M.
    Shaw, J.
    Magliano, D.
    Date
    2016
    Type
    Journal Article
    
    Metadata
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    Citation
    Harding, J. and Sooriyakumaran, M. and Anstey, K. and Adams, R. and Balkau, B. and Brennan-Olsen, S. and Briffa, T. et al. 2016. Hypertension, antihypertensive treatment and cancer incidence and mortality: A pooled collaborative analysis of 12 Australian and New Zealand cohorts. Journal of Hypertension. 34 (1): pp. 149-155.
    Source Title
    Journal of Hypertension
    DOI
    10.1097/HJH.0000000000000770
    ISSN
    0263-6352
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/23110
    Collection
    • Curtin Research Publications
    Abstract

    Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. Background: Observational studies examining associations between hypertension and cancer are inconsistent. We explored the association of hypertension, graded hypertension and antihypertensive treatment with cancer incidence and mortality. Method: Eighty-six thousand five hundred and ninety-three participants from the Australian and New Zealand Diabetes and Cancer Collaboration were linked to the National Death Index and Australian Cancer Database. Cox proportional hazards models estimated hazard ratios and 95% confidence intervals (95% CI) for the association of treated and untreated hypertension with cancer incidence and mortality. Results: Over a median follow-up of 15.1 years, 12 070 incident and 4350 fatal cancers were identified. Untreated and treated hypertension, compared with normotension, were associated with an increased risk for cancer incidence [hazard ratio 1.06, 95% CI (1.00-1.11) and 1.09 (1.02-1.16) respectively], and cancer mortality (1.07, 0.98-1.18) and (1.15, 1.03-1.28), respectively. When compared with untreated hypertension, treated hypertension did not have a significantly greater risk for cancer incidence (1.03, 0.97-1.10) or mortality (1.07, 0.97-1.19). A significant dose-response relationship was observed between graded hypertension and cancer incidence and mortality; P trend = 0.053 and P trend = 0.001, respectively. When stratified by treatment status, these relationships remained significant in untreated, but not in treated, hypertension. Conclusion: Hypertension, both treated and untreated, is associated with a modest increased risk for cancer incidence and mortality. Similar risks in treated and untreated hypertension suggest that the increased cancer risk is not explained by the use of antihypertensive treatment.

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