Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Pharmacological role of efflux transporters: Clinical implications for medication use during breastfeeding

    212632_138897_85848_Ahmadzai_Tee_Crowe__published_.pdf (773.3Kb)
    Access Status
    Open access
    Authors
    Ahmadzai, Hilai
    Tee, Lisa
    Crowe, Andrew
    Date
    2014
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Ahmadzai, H. and Tee, L. and Crowe, A. 2014. Pharmacological role of efflux transporters: Clinical implications for medication use during breastfeeding. World Journal of Pharmacology. 3 (4): pp. 153-161.
    Source Title
    World Journal of Pharmacology
    DOI
    10.5497/wjp.v3.i4.153
    ISSN
    2220-3192
    School
    School of Pharmacy
    Remarks

    This article is published under the Open Access publishing model and distributed under the terms of the Creative Commons License http://creativecommons.org/licenses/by-nc/4.0/ Please refer to the licence to obtain terms for any further reuse or distribution of this work.

    URI
    http://hdl.handle.net/20.500.11937/23197
    Collection
    • Curtin Research Publications
    Abstract

    The World Health Organisation recommends exclusive breastfeeding for the first six months of an infant’s life and in combination with solid food thereafter. This recommendation was introduced based on research showing numerous health benefits of breastfeeding for both the mother and the infant. However, there is always concern regarding the transfer of medications from mother to their breastfed baby via milk. Pharmacokinetic properties of a drug are usually used to predict its transferability into breast milk. Although most drugs are compatible with breastfeeding, cases of toxic drug exposure have been reported. This is thought to be due to active transport mechanisms whereby efflux transporter proteins expressed in the epithelial cells of the mammary gland actively secrete drugs into milk. An example of such efflux transporters including the breast cancer resistance protein which is strongly induced during lactation and this could result in contamination of milk with the substrates of this transporter which may place the suckling infant at risk of toxicity. Furthermore, there is little known about the substrate specificity of most efflux transporters as we have highlighted in this review. There also exists some degree of contradiction between in vivo and in vitro studies which makes it difficult to conclusively predict outcomes and drug-drug interactions.

    Related items

    Showing items related by title, author, creator and subject.

    • Factors that influence breastfeeding initiation and duration in urban, suburban and rural areas of Zhejiang Province, Peoples Republic of China
      Qiu, Liqian (2008)
      Introduction: Breast milk is the best way to feed all infants. It results in better nutrition for the infant and to reduced rates of chronic disease later in childhood and adulthood. Breastfed babies have lower rates of ...
    • Breastfeeding and health outcomes in infants who receive continuing care from hospitals or community health centres in Chengdu Sichuan Province, People’s Republic of China
      Yu, Chuan (2013)
      Introduction. The child health is one of the most important indicators of population health and the development of society. The health of children in China has improved in the past decades. The child health care system ...
    • Transfer of methylamphetamine and amphetamine into breast milk following recreational use of methylamphetamine
      Bartu, Anne; Dusci, L.; Ilett, K. (2009)
      AIMS To investigate the transfer of amphetamines into breast milk following their recreational use and estimate drug exposure for the breastfed infant. METHODS Two breastfeeding mothers who were occasional recreational ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.