Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Long-term RNA persistence in postmortem contexts

    Access Status
    Fulltext not available
    Authors
    Fordyce, S.
    Kampmann, M.
    L van Doom, N.
    Gilbert, Thomas
    Date
    2013
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Fordyce, S. and Kampmann, M. and L van Doom, N. and Gilbert, T. 2013. Long-term RNA persistence in postmortem contexts. Investigative Genetics. 4.
    Source Title
    Investigative Genetics
    Additional URLs
    http://www.biomedcentral.com/content/pdf/2041-2223-4-7.pdf
    ISSN
    2041-2223
    URI
    http://hdl.handle.net/20.500.11937/23277
    Collection
    • Curtin Research Publications
    Abstract

    Ribonucleic acids (RNA) are generally considered fragile molecules that are readily degraded. However, there is growing documentation of long-term (from days to centuries) RNA persistence in a variety of contexts and tissue types, and as such a number of academic disciplines are beginning to exploit degraded RNA. While the reasons for its survival are not fully understood, there are several plausible mechanisms that would safeguard this molecule against degradation. However, after examining the literature available on the postmortem instability and decay mechanisms of RNA, it has become clear that limited experimental studies and no reviews offer an overview of these mechanisms. Hence in this review we outline molecular reasons for RNA surviving long-term postmortem, and provide specific examples of RNA survival in forensic, archival and archaeological contexts. A better understanding of the mechanisms of RNA decay will be crucial for developing expectations on its long-term survival.

    Related items

    Showing items related by title, author, creator and subject.

    • Long-Term Outcomes of Unprotected Left Main Percutaneous Coronary Intervention in Centers Without Onsite Cardiac Surgery
      Hanson, L.; Vogrin, S.; Noaman, S.; Dinh, D.; Zheng, W.; Lefkovits, J.; Brennan, A.; Reid, Christopher ; Stub, D.; Duffy, S.J.; Layland, J.; Freeman, M.; van Gaal, W.; Cox, N.; Chan, W. (2022)
      Unprotected left main (LM) percutaneous coronary intervention (PCI) at centers without onsite cardiac surgery remains controversial. We aimed to evaluate the effect of onsite cardiac surgery on short-term and long-term ...
    • Long-term survival of elderly patients undergoing percutaneous coronary intervention for myocardial infarction complicated by cardiogenic shock
      Lim, H.; Andrianpoulos, N.; Sugumar, H.; Stub, D.; Brennan, A.; Reid, Christopher; Lim, C.; Barlis, P. (2015)
      Background: The long-term benefit of early percutaneous coronary intervention (PCI) for cardiogenic shock (CS) in elderly patients remains unclear. We sought to assess the long-term survival of elderly patients (age ≥ 75 ...
    • Impact of door-to-balloon time on long-term mortality in high- and low-risk patients with ST-elevation myocardial infarction
      Yudi, M.; Ramchand, J.; Farouque, O.; Andrianopoulos, N.; Chan, W.; Duffy, S.; Lefkovits, J.; Brennan, A.; Spencer, R.; Fernando, D.; Hiew, C.; Freeman, M.; Reid, Christopher; Ajani, A.; Clark, D. (2016)
      © 2016Background Door-to-balloon time (DTBT) less than 90 min remains the benchmark of timely reperfusion in ST-elevation myocardial infarction (STEMI). The relative long-term benefit of timely reperfusion in STEMI patients ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.