Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Kupffer cell-monocyte communication is essential for initiating murine liver progenitor cell-mediated liver regeneration

    229984_229984.pdf (672.7Kb)
    Access Status
    Open access
    Authors
    Elsegood, Caryn
    Chan, C.
    Degli-Esposti, M.
    Wikstrom, M.
    Domenichini, A.
    Lazarus, K.
    van Rooijen, N.
    Ganss, R.
    Olynyk, John
    Yeoh, G.
    Date
    2015
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Elsegood, C. and Chan, C. and Degli-Esposti, M. and Wikstrom, M. and Domenichini, A. and Lazarus, K. and van Rooijen, N. et al. 2015. Kupffer cell-monocyte communication is essential for initiating murine liver progenitor cell-mediated liver regeneration. Hepatology. 62 (4): pp. 1272-1284.
    Source Title
    Hepatology
    DOI
    10.1002/hep.27977
    ISSN
    0270-9139
    School
    School of Biomedical Sciences
    Remarks

    This is the peer reviewed version of the following article: "Elsegood, C., Chan, C., Degli-Esposti, M., et al. 2015. Hepatology. 62 (4): pp. 1272-1284.", which has been published in final form at http://doi.org/10.1002/hep.27977. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving at http://olabout.wiley.com/WileyCDA/Section/id-820227.html#terms

    URI
    http://hdl.handle.net/20.500.11937/23478
    Collection
    • Curtin Research Publications
    Abstract

    Liver progenitor cells (LPCs) are necessary for repair in chronic liver disease because the remaining hepatocytes cannot replicate. However, LPC numbers also correlate with disease severity and hepatocellular carcinoma risk. Thus, the progenitor cell response in diseased liver may be regulated to optimize liver regeneration and minimize the likelihood of tumorigenesis. How this is achieved is currently unknown. Human and mouse diseased liver contain two subpopulations of macrophages with different ontogenetic origins: prenatal yolk sac-derived Kupffer cells and peripheral blood monocyte-derived macrophages. We examined the individual role(s) of Kupffer cells and monocyte-derived macrophages in the induction of LPC proliferation using clodronate liposome deletion of Kupffer cells and adoptive transfer of monocytes, respectively, in the choline-deficient, ethionine-supplemented diet model of liver injury and regeneration. Clodronate liposome treatment reduced initial liver monocyte numbers together with the induction of injury and LPC proliferation. Adoptive transfer of monocytes increased the induction of liver injury, LPC proliferation, and tumor necrosis factor-a production. Conclusion: Kupffer cells control the initial accumulation of monocyte-derived macrophages. These infiltrating monocytes are in turn responsible for the induction of liver injury, the increase in tumor necrosis factor-a, and the subsequent proliferation of LPCs.

    Related items

    Showing items related by title, author, creator and subject.

    • Invading macrophages play a major role in the liver progenitor cell response to chronic liver injury
      Viebahn, C.; Benseler, V.; Holz, L.; Elsegood, Caryn; Vo, M.; Bertolino, P.; Ganss, R.; Yeoh, G. (2010)
      Background & Aims: Although a strong association between liver progenitor cells (LPCs) and inflammation exists in many chronic liver diseases, the exact role of the immune system in LPC-mediated hepatic regeneration remains ...
    • TWEAK/Fn14 signalling promotes cholangiocarcinoma niche formation and progression
      Dwyer, Ben ; Jarman, E.J.; Gogoi-Tiwari, Jully ; Ferreira-Gonzalez, S.; Boulter, L.; Guest, R.V.; Kendall, T.J.; Kurian, D.; Kilpatrick, A.M.; Robson, A.J.; O'Duibhir, E.; Man, T.Y.; Campana, L.; Starkey Lewis, P.J.; Wigmore, S.J.; Olynyk, John ; Ramm, G.A.; Tirnitz-Parker, Nina ; Forbes, S.J. (2021)
      Background & Aims: Cholangiocarcinoma (CCA) is a cancer of the hepatic bile ducts that is rarely resectable and is associated with poor prognosis. Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) is known to ...
    • Development of Kupffer cell targeting type-I interferon for the treatment of hepatitis via inducing anti-inflammatory and immunomodulatory actions
      Minayoshi, Y.; Maeda, H.; Yanagisawa, H.; Hamasaki, K.; Mizuta, Y.; Nishida, K.; Kinoshita, R.; Enoki, Y.; Imafuku, T.; Chuang, Victor; Koga, T.; Fujiwara, Y.; Takeya, M.; Sonoda, K.; Wakayama, T.; Taguchi, K.; Ishima, Y.; Ishida, T.; Iwakiri, Y.; Tanaka, M.; Sasaki, Y.; Watanabe, H.; Otagiri, M.; Maruyama, T. (2018)
      Because of its multifaceted anti-inflammatory and immunomodulatory effects, delivering type-I interferon to Kupffer cells has the potential to function as a novel type of therapy for the treatment of various types of ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.