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    Vitamin D: Metabolism, Molecular Mechanisms, and Mutations to Malignancies

    Access Status
    Fulltext not available
    Authors
    Nemazannikova, N.
    Antonas, K.
    Dass, Crispin
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Nemazannikova, N. and Antonas, K. and Dass, C. 2014. Vitamin D: Metabolism, Molecular Mechanisms, and Mutations to Malignancies. Molecular Carcinogenesis. 53 (6): pp. 421-431.
    Source Title
    Molecular Carcinogenesis
    DOI
    10.1002/mc.21999
    ISSN
    0899-1987
    URI
    http://hdl.handle.net/20.500.11937/23500
    Collection
    • Curtin Research Publications
    Abstract

    The potential protective effects of vitamin D against cutaneous carcinogenesis are still poorly understood. The inhibition, by vitamin D, of various cancers in in vitro and in vivo models has triggered detailed investigation of vitamin D effects on neoplastic behavior. Recent studies highlight that such neoplastic features as the tumor microenvironment, angiogenesis, DNA mutagenesis, and apoptosis are all connected to vitamin D metabolic pathways. This review discusses these connections. Vitamin D modulation of the cell cycle, DNA repair and apoptosis via its receptors (VDRs) may have a suppressive effect on skin cancer as some studies suggest. The regulation of multiple tumor signaling pathways by vitamin D may have an implication in cutaneous carcinogenesis and tumor progression to malignancy.

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