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    Subtilomycin: A New Lantibiotic from Bacillus subtilis Strain MMA7 Isolated from the Marine Sponge Haliclona simulans

    Access Status
    Open access via publisher
    Authors
    Phelan, Robert
    Barret, Matthieu
    Cotter, Paul
    O’Connor, Paula
    Chen, Rui
    Morrissey, John
    Dobson, Alan
    O'Gara, Fergal
    Barbosa, Teresa
    Date
    2013
    Type
    Journal Article
    
    Metadata
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    Citation
    Phelan, Robert and Barret, Matthieu and Cotter, Paul and O’Connor, Paula and Chen, Rui and Morrissey, John and Dobson, Alan and O'Gara, Fergal and Barbosa, Teresa. 2013. Subtilomycin: A New Lantibiotic from Bacillus subtilis Strain MMA7 Isolated from the Marine Sponge Haliclona simulans. Marine Drugs. 11: pp. 1878-1898.
    Source Title
    Marine Drugs
    DOI
    10.3390/md11061878
    ISSN
    1660-3397
    URI
    http://hdl.handle.net/20.500.11937/23902
    Collection
    • Curtin Research Publications
    Abstract

    Bacteriocins are attracting increased attention as an alternative to classic antibiotics in the fight against infectious disease and multidrug resistant pathogens. Bacillus subtilis strain MMA7 isolated from the marine sponge Haliclona simulans displays a broad spectrum antimicrobial activity, which includes Gram-positive and Gram-negative pathogens, as well as several pathogenic Candida species. This activity is in part associated with a newly identified lantibiotic, herein named as subtilomycin. The proposed biosynthetic cluster is composed of six genes, including protein-coding genes for LanB-like dehydratase and LanC-like cyclase modification enzymes, characteristic of the class I lantibiotics. The subtilomycin biosynthetic cluster in B. subtilis strain MMA7 is found in place of the sporulation killing factor (skf) operon, reported in many B. subtilis isolates and involved in a bacterial cannibalistic behaviour intended to delay sporulation. The presence of the subtilomycin biosynthetic cluster appears to be widespread amongst B. subtilis strains isolated from different shallow and deep water marine sponges. Subtilomycin possesses several desirable industrial and pharmaceutical physicochemical properties, including activity over a wide pH range, thermal resistance and water solubility. Additionally, the production of the lantibiotic subtilomycin could be a desirable property should B. subtilis strain MMA7 be employed as a probiotic in aquaculture applications.

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