Five-Year Decline in Estimated Glomerular Filtration Rate Associated With a Higher Risk of Renal Disease and Atherosclerotic Vascular Disease Clinical Events in Elderly Women

Abstract

Background: Estimated glomerular filtration rate (eGFR) has been demonstrated to predict atherosclerotic vascular disease (ASVD)-associated clinical events independent of traditional vascular risk factors. Recent studies have demonstrated that eGFR decline over time may improve prediction of ASVD-associated mortality risk in chronic kidney disease (CKD) patients. Aim: The aim of this study is to evaluate the association between 5-year change in eGFR with renal disease and ASVD-associated clinical events. Design: Prospective observational study. Methods: A total of 1012 women over the age of 70 years from the Calcium Intake Fracture Outcome Study were included. Baseline characteristics including baseline and 5-year creatinine, participants’ comorbidities and complete verified 10-year records for ASVD and renal disease-associated hospitalization and/or mortality were obtained using the Western Australian Data Linkage System. Results: Participants were stratified according to annual rate of eGFR change in quartiles [≤−1.2 (first quartile), >−1.2 to 0.1 (second quartile), >0.1–1.7 (third quartile) and >1.7 ml/min/1.73 m2/year (fourth quartile)]. In the adjusted model, compared with participants in the fourth quartile, those in the first and/or second quartiles of annual eGFR change had significantly higher risk of renal disease and/or ASVD-associated clinical events. However, the association with renal clinical events was more apparent in participants with baseline eGFR of <60 ml/min/1.73 m2. Conclusion: The results of this study suggest that the inclusion of long-term eGFR change over time might augment prognostication for renal disease and ASVD-associated clinical events in elderly women.