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dc.contributor.authorHuxley, Rachel
dc.contributor.authorAlonso, A.
dc.contributor.authorLopez, F.
dc.contributor.authorFilion, K.
dc.contributor.authorAgarwal, S.
dc.contributor.authorLoehr, L.
dc.contributor.authorSoliman, E.
dc.contributor.authorPankow, J.
dc.contributor.authorSelvin, E.
dc.date.accessioned2017-01-30T12:43:28Z
dc.date.available2017-01-30T12:43:28Z
dc.date.created2016-02-04T19:30:29Z
dc.date.issued2012
dc.identifier.citationHuxley, R. and Alonso, A. and Lopez, F. and Filion, K. and Agarwal, S. and Loehr, L. and Soliman, E. et al. 2012. Type 2 diabetes, glucose homeostasis and incident atrial fibrillation: The Atherosclerosis risk in communities study. Heart. 98 (2): pp. 133-138.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/24516
dc.identifier.doi10.1136/heartjnl-2011-300503
dc.description.abstract

Background: Type 2 diabetes has been inconsistently associated with the risk of atrial fibrillation (AF) in previous studies that have frequently been beset by methodological challenges. Design: Prospective cohort study. Setting: The Atherosclerosis Risk in Communities (ARIC) study. Participants: Detailed medical histories were obtained from 13 025 participants. Individuals were categorised as having no diabetes, pre-diabetes or diabetes based on the 2010 American Diabetes Association criteria at study baseline (1990-2). Main outcome measures: Diagnoses of incident AF were obtained to the end of 2007. Associations between type 2 diabetes and markers of glucose homeostasis and the incidence of AF were estimated using Cox proportional hazards models after adjusting for possible confounders. Results: Type 2 diabetes was associated with a significant increase in the risk of AF (HR 1.35, 95% CI 1.14 to 1.60) after adjustment for confounders. There was no indication that individuals with pre-diabetes or those with undiagnosed diabetes were at increased risk of AF compared with those without diabetes. A positive linear association was observed between HbA1c and the risk of AF in those with and without diabetes (HR 1.13, 95% CI 1.07 to 1.20) and HR 1.05, 95% CI 0.96 to 1.15 per 1% point increase, respectively). There was no association between fasting glucose or insulin in those without diabetes, but a significant association with fasting glucose was found in those with the condition. The results were similar in white subjects and African-Americans. Conclusions: Diabetes, HbA1c level and poor glycaemic control are independently associated with an increased risk of AF, but the underlying mechanisms governing the relationship are unknown and warrant further investigation.

dc.titleType 2 diabetes, glucose homeostasis and incident atrial fibrillation: The Atherosclerosis risk in communities study
dc.typeJournal Article
dcterms.source.volume98
dcterms.source.number2
dcterms.source.startPage133
dcterms.source.endPage138
dcterms.source.issn1355-6037
dcterms.source.titleHeart
curtin.departmentSchool of Public Health
curtin.accessStatusFulltext not available


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