Older maternal age is associated with depression, anxiety, and stress symptoms in young adult female offspring
MetadataShow full item record
The evidence regarding older parental age and incidence of mood disorder symptoms in offspring is limited, and that which exists is mixed. We sought to clarify these relationships by using data from the Western Australian Pregnancy Cohort (Raine) Study. The Raine Study provided comprehensive data from 2,900 pregnancies, resulting in 2,868 live born children. A total of 1,220 participants completed the short form of the Depression Anxiety Stress Scale (DASS-21) at the 20-year cohort follow-up. We used negative binomial regression analyses with log link and with adjustment for known perinatal risk factors to examine the extent to which maternal and paternal age at childbirth predicted continuous DASS-21 index scores. In the final multivariate models, a maternal age of 30–34 years was associated with significant increases in stress DASS-21 scores in female offspring relative to female offspring of 25- to 29-year-old mothers. A maternal age of 35 years and over was associated with increased scores on all DASS-21 scales in female offspring. Our results indicate that older maternal age is associated with depression, anxiety, and stress symptoms in young adult females. Further research into the mechanisms underpinning this relationship is needed.
Showing items related by title, author, creator and subject.
Sex differences between parental pregnancy characteristics and nonalcoholic fatty liver disease in adolescentsAyonrinde, Oyekoya; Adams, L.; Mori, T.; Beilin, L.; de Klerk, N.; Pennell, C.; White, S.; Olynyk, John (2018)Nonalcoholic fatty liver disease (NAFLD) is a complex chronic liver disorder. Examination of parental pregnancy-related characteristics may provide insights into the origins of risk of NAFLD in offspring. We examined ...
Li, Jianghong; Robinson, Monique; Malacova, Eva; Jacoby, Peter; Foster, Jonathan; van Eekelen, Anke (2013)Objective: To test the hypothesis that maternal antenatal exposure to life stress events is associated with lower achievement in literacy and numeracy at age 10 years, with sex differences in this link. Study design: The ...
Association of pre- and post-natal parental smoking with offspring body mass index: An 8-year follow-up of a birth cohortFlorath, Ines; Kohler, M.; Weck, M.; Brandt, S.; Rothenbacher, D.; Schöttker, B.; Moß, A.; Gottmann, P.; Wabitsch, M.; Brenner, H. (2014)© 2013 The Authors. Pediatric Obesity © 2013 International Association for the Study of Obesity. Summary What is already known about this subject Maternal smoking during pregnancy is associated with offspring overweight, ...