A New, One-Pot, Multicomponent Synthesis of Bioactive N -Pyrazolylformamidines under Microwave Irradiation
dc.contributor.author | Lim, F. | |
dc.contributor.author | Luna, G. | |
dc.contributor.author | Dolzhenko, Anton | |
dc.date.accessioned | 2017-01-30T12:44:20Z | |
dc.date.available | 2017-01-30T12:44:20Z | |
dc.date.created | 2016-08-10T19:30:17Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Lim, F. and Luna, G. and Dolzhenko, A. 2016. A New, One-Pot, Multicomponent Synthesis of Bioactive N -Pyrazolylformamidines under Microwave Irradiation. Synthesis. 48 (15): pp. 2423-2428. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/24652 | |
dc.identifier.doi | 10.1055/s-0035-1561616 | |
dc.description.abstract |
A one-pot, three-component, microwave-assisted reaction of polysubstituted 5-aminopyrazoles, triethyl orthoformate, and a series of cyclic secondary amines was developed and successfully employed for the synthesis of novel N-pyrazolylformamidines. Under catalyst-free conditions, the reaction proceeded in a chemo- and regioselective manner, resulting in the formation of unsymmetric formamidines, which were isolated in high yields and purity. Some of the prepared compounds were found to inhibit interleukin-17 secretion in phenotypic in vitro assays. | |
dc.publisher | Georg Thieme Verlag | |
dc.title | A New, One-Pot, Multicomponent Synthesis of Bioactive N -Pyrazolylformamidines under Microwave Irradiation | |
dc.type | Journal Article | |
dcterms.source.volume | 48 | |
dcterms.source.number | 15 | |
dcterms.source.startPage | 2423 | |
dcterms.source.endPage | 2428 | |
dcterms.source.issn | 0039-7881 | |
dcterms.source.title | Synthesis | |
curtin.department | School of Pharmacy | |
curtin.accessStatus | Fulltext not available |
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