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dc.contributor.authorLim, F.
dc.contributor.authorLuna, G.
dc.contributor.authorDolzhenko, Anton
dc.date.accessioned2017-01-30T12:44:20Z
dc.date.available2017-01-30T12:44:20Z
dc.date.created2016-08-10T19:30:17Z
dc.date.issued2016
dc.identifier.citationLim, F. and Luna, G. and Dolzhenko, A. 2016. A New, One-Pot, Multicomponent Synthesis of Bioactive N -Pyrazolylformamidines under Microwave Irradiation. Synthesis. 48 (15): pp. 2423-2428.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/24652
dc.identifier.doi10.1055/s-0035-1561616
dc.description.abstract

A one-pot, three-component, microwave-assisted reaction of polysubstituted 5-aminopyrazoles, triethyl orthoformate, and a series of cyclic secondary amines was developed and successfully employed for the synthesis of novel N-pyrazolylformamidines. Under catalyst-free conditions, the reaction proceeded in a chemo- and regioselective manner, resulting in the formation of unsymmetric formamidines, which were isolated in high yields and purity. Some of the prepared compounds were found to inhibit interleukin-17 secretion in phenotypic in vitro assays.

dc.publisherGeorg Thieme Verlag
dc.titleA New, One-Pot, Multicomponent Synthesis of Bioactive N -Pyrazolylformamidines under Microwave Irradiation
dc.typeJournal Article
dcterms.source.volume48
dcterms.source.number15
dcterms.source.startPage2423
dcterms.source.endPage2428
dcterms.source.issn0039-7881
dcterms.source.titleSynthesis
curtin.departmentSchool of Pharmacy
curtin.accessStatusFulltext not available


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