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    The effect of diesel exhaust exposure on blood-brain barrier integrity and function in a murine model

    Access Status
    Fulltext not available
    Authors
    Heidari Nejad, S.
    Takechi, Ryu
    Mullins, B.
    Giles, C.
    Larcombe, A.
    Bertolatti, Dean
    Rumchev, K.
    Dhaliwal, S.
    Mamo, John
    Date
    2015
    Type
    Journal Article
    
    Metadata
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    Citation
    Heidari Nejad, S. and Takechi, R. and Mullins, B. and Giles, C. and Larcombe, A. and Bertolatti, D. and Rumchev, K. et al. 2015. The effect of diesel exhaust exposure on blood-brain barrier integrity and function in a murine model. Journal of Applied Toxicology. 35 (1): pp. 41-47.
    Source Title
    Journal of Applied Toxicology
    DOI
    10.1002/jat.2985
    ISSN
    0260-437X
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/24933
    Collection
    • Curtin Research Publications
    Abstract

    Epidemiological studies indicate that exposure to diesel exhaust (DE) is associated with vascular-based disorders. To investigate the effect of DE on blood-brain barrier (BBB) function and integrity, 8-week-old BALB/c mice were randomized to DE in a cyclical treatment regimen over a 2-week period. Functional integrity of BBB was determined by considering brain parenchymal abundance of IgG within the hippocampal formation and cortex at 6h and 24h intervals following final exposure treatment. Neurovascular inflammation was expressed as the abundance of glial fibrillar acidic protein. Two doses of DE were studied and compared to air-only treated mice. Mice exposed to DE had substantially greater abundance of parenchymal IgG compared to control mice not exposed to DE. Increased parenchymal glial fibrillar acidic protein at 24h post-DE exposure suggested heightened neurovascular inflammation. Our findings are proof-of-concept that inhalation of DE can compromise BBB function and support the broader contention that DE exposure may contribute to neurovascular disease risk.

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