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    Wnt Signaling Regulation of Tissue Architecture (EMT and MET) and Morphogenesis: Consequences for Colorectal and Liver Cancer

    Access Status
    Fulltext not available
    Authors
    Fifis, T.
    Tran, B.
    Schwab, R.
    Johanson, T.
    Warner, N.
    Barker, N.
    Vincan, Elizabeth
    Date
    2014
    Type
    Book Chapter
    
    Metadata
    Show full item record
    Citation
    Fifis, T. and Tran, B. and Schwab, R. and Johanson, T. and Warner, N. and Barker, N. and Vincan, E. 2014. Wnt Signaling Regulation of Tissue Architecture (EMT and MET) and Morphogenesis: Consequences for Colorectal and Liver Cancer. In Wnt Signaling in Development and Disease: Molecular Mechanisms and Biological Functions, 315-328: Wiley Blackwell.
    Source Title
    Wnt Signaling in Development and Disease: Molecular Mechanisms and Biological Functions
    DOI
    10.1002/9781118444122.ch24
    ISBN
    9781118444160
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/24997
    Collection
    • Curtin Research Publications
    Abstract

    © 2014 John Wiley & Sons, Inc. The different branches of the Wnt signaling pathway were first characterized in developmental contexts, but in recent times, each branch has been implicated in tumor growth and progression. This chapter exemplifies this link between development and cancer by focusing on two Wnt-driven cancers, colorectal cancer (CRC) and hepatocellular carcinoma (HCC). It focuses on the processes of epithelial-to-mesenchymal transition (EMT) and the reverse transition, mesenchymal-to-epithelial transition (MET), both fundamental mechanisms of tumor metastasis and morphogenesis. HCC shares many parallels with CRC with respect to the involvement of Wnt signaling in cancer initiation and progression.

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