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    Reactive amine surfaces for biosensor applications, prepared by plasma-enhanced chemical vapour modification of polyolefin materials

    154411_154411.pdf (745.6Kb)
    Access Status
    Open access
    Authors
    Volcke, C.
    Gandhiraman, R.
    Gubala, V.
    Raj, J.
    Cummins, T.
    Fonder, G.
    Nooney, R.
    Mekhalif, Z.
    Herzog, G.
    Daniels, S.
    Arrigan, Damien
    Cafolla, A.
    Williams, D.
    Date
    2010
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Volcke, Cedric and Gandhiraman, R and Gubala, V and Raj, Jog and Cummins, T and Fonder, G and Nooney, R and Mekhalif, Z and Herzog, Gregoire and Daniels, S and Arrigan, Damien and Cafolla, A and Williams, D. 2010. Reactive amine surfaces for biosensor applications, prepared by plasma-enhanced chemical vapour modification of polyolefin materials. Biosensors and Bioelectronics. 25 (8): pp. 1875-1880.
    Source Title
    Biosensors and Bioelectronics
    DOI
    10.1016/j.bios.2009.12.034
    ISSN
    09565663
    School
    Nanochemistry Research Institute (Research Institute)
    Remarks

    NOTICE: this is the author’s version of a work that was accepted for publication in Biosensors and Bioelectronics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Biosensors and Bioelectronics, vol. 25, no. 8 (2010) http://dx.doi.org/10.1016/j.bios.2009.12.034

    URI
    http://hdl.handle.net/20.500.11937/25059
    Collection
    • Curtin Research Publications
    Abstract

    Here we have demonstrated a solventless plasma-based process that integrates low-cost, high throughput,high reproducibility and ecofriendly process for the functionalization of the next-generationpoint-of-care device platforms. Amine functionalities were deposited by plasma-enhanced chemicalvapour deposition (PECVD) using a new precursor. The influence of the plasma RF power and the deposition time on surfacial properties, as well as their effect on the reactivity and content of amino groups was investigated. The key process determinants were to have a sufficient power in the plasma to activate and partially fragment the monomer but not too much as to lose the reactive amine functionality, and sufficient deposition time to develop a reactive layer but not to consume or erode the amine reactivity. An immunoassay performed using human immunoglobulin (IgG) as a model analyte showed an improvement of the detection limit by two orders of magnitude beyond that obtained using devices activated by liquid-phase reaction.

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