Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Nutrient regulation of insulin secretion and ß-cell functional integrity

    Access Status
    Fulltext not available
    Authors
    Newsholme, Philip
    Gaudel, C.
    McClenaghan, N.
    Date
    2010
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Newsholme, P. and Gaudel, C. and McClenaghan, N. 2010. Nutrient regulation of insulin secretion and ß-cell functional integrity. Advances in Experimental Medicine and Biology. 654: pp. 91-114.
    Source Title
    Advances in Experimental Medicine and Biology
    DOI
    10.1007/978-90-481-3271-3_6
    ISSN
    0065-2598
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/25758
    Collection
    • Curtin Research Publications
    Abstract

    Pancreatic ß-cells are often referred to as "fuel sensors" as they continually monitor and respond to dietary nutrients, under the modulation of additional neurohormonal signals, in order to secrete insulin to best meet the needs of the organism. ß-cell nutrient sensing requires metabolic activation, resulting in production of stimulus-secretion coupling signals that promote insulin biosynthesis and release. The primary stimulus for insulin secretion is glucose, and islet ß-cells are particularly responsive to this important nutrient secretagogue, It is important to consider individual effects of different classes of nutrient or other physiological or pharmacological agents on metabolism and insulin secretion. However, given that ß-cells are continually exposed to a complex milieu of nutrients and other circulating factors, it is important to also acknowledge and examine the interplay between glucose metabolism and that of the two other primary nutrient classes, the amino acids and fatty acids. It is the mixed nutrient sensing and outputs of glucose, amino and fatty acid metabolism that generate the metabolic coupling factors (MCFs) involved in signaling for insulin exocytosis. Primary MCFs in the ß-cell include ATP, NADPH, glutamate, long chain acyl-CoA and diacylglycerol and are discussed in detail in this article. © Springer Science+Business Media B.V. 2010.

    Related items

    Showing items related by title, author, creator and subject.

    • Nutritional Regulation of Insulin Secretion: Implications for Diabetes
      Newsholme, Philip; Krause, M. (2012)
      Pancreatic ß-cells are exquisitely organised to continually monitor and respond to dietary nutrients, under the modulation of additional neurohormonal signals, in order to secrete insulin to best meet the needs of the ...
    • Nutrient regulation of insulin secretion and action
      Newsholme, Philip; Cruzat, Vinicius; Arfuso, Frank; Keane, Kevin (2014)
      Pancreatic ß-cell function is of critical importance in the regulation of fuel homoeostasis, and metabolic dysregulation is a hallmark of diabetes mellitus (DM). The ß-cell is an intricately designed cell type that couples ...
    • Elevated levels of branched-chain amino acids have little effect on pancreatic islet cells, but L-arginine impairs function through activation of the endoplasmic reticulum stress response
      Mullooly, N.; Vernon, W.; Smith, D.; Newsholme, Philip (2014)
      New Findings - What is the central question of this study?: Recent studies have demonstrated strong correlations between circulating branched-chain amino acid (AA) levels and insulin resistance, a predictor of susceptibility ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.