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    Cost-Effectiveness of Carrier Screening for Cystic Fibrosis in Australia

    Access Status
    Open access via publisher
    Authors
    Norman, Richard
    Van Gool, K.
    Hall, J.
    Delatycki, M.
    Massie, J.
    Date
    2012
    Type
    Journal Article
    
    Metadata
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    Citation
    Norman, R. and Van Gool, K. and Hall, J. and Delatycki, M. and Massie, J. 2012. Cost-Effectiveness of Carrier Screening for Cystic Fibrosis in Australia. Journal of Cystic Fibrosis. 11: pp. 281-287.
    Source Title
    Journal of Cystic Fibrosis
    DOI
    10.1016/j.jcf.2012.02.007
    ISSN
    1569-1993
    URI
    http://hdl.handle.net/20.500.11937/25772
    Collection
    • Curtin Research Publications
    Abstract

    Background: Carrier screening for cystic fibrosis is not widely available in Australia, partly due to concerns regarding its cost-effectiveness. The benefit of information from pregnancy to pregnancy has not been widely considered in existing cost-effectiveness analyses.Methods: A decision tree was constructed estimating costs and outcomes from screening, including both initial and subsequent pregnancies. Effectiveness was expressed in terms of CF births averted. Costs were collected using a health service perspective. All costs and outcomes were discounted at 5% per annum.Results: Screening reduced the annual incidence of CF births from 34 to 14/100,000 births (an aggregate number of CF births of 100.9 and 41.9 respectively). In initial pregnancies, costs in the screening arm (A$16.6 million/100,000 births) exceed those in the non-screening arm (A $13.4 million/100,000 births). The incremental cost per CF birth in initial pregnancies is therefore approximately A$150,000. However, this was reversed for subsequent pregnancies, in that the pre-collected information reduces the incidence of CF in subsequent pregnancies at low additional costs.When aggregated, the results suggest screening is likely to be cost-saving.Conclusions: The introduction of national carrier screening for cystic fibrosis should be considered, as it is likely to reduce CF incidence at an acceptable (potentially negative) cost.

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