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dc.contributor.authorHansen, T.
dc.contributor.authorMollerup, S.
dc.contributor.authorNguyen, N.
dc.contributor.authorWhite, Nicole
dc.contributor.authorCoghlan, Megan
dc.contributor.authorAlquezar-Planas, D.
dc.contributor.authorJoshi, T.
dc.contributor.authorJensen, R.
dc.contributor.authorFridholm, H.
dc.contributor.authorKjartansdóttir, K.
dc.contributor.authorMourier, T.
dc.contributor.authorWarnow, T.
dc.contributor.authorBelsham, G.
dc.contributor.authorBunce, Michael
dc.contributor.authorWillerslev, E.
dc.contributor.authorNielsen, L.
dc.contributor.authorVinner, L.
dc.contributor.authorHansen, A.
dc.identifier.citationHansen, T. and Mollerup, S. and Nguyen, N. and White, N. and Coghlan, M. and Alquezar-Planas, D. and Joshi, T. et al. 2016. High diversity of picornaviruses in rats from different continents revealed by deep sequencing. Emerging Microbes & Infections. 5: e90.

Outbreaks of zoonotic diseases in humans and livestock are not uncommon, and an important component in containment of such emerging viral diseases is rapid and reliable diagnostics. Such methods are often PCR-based and hence require the availability of sequence data from the pathogen. Rattus norvegicus (R. norvegicus) is a known reservoir for important zoonotic pathogens. Transmission may be direct via contact with the animal, for example, through exposure to its faecal matter, or indirectly mediated by arthropod vectors. Here we investigated the viral content in rat faecal matter (n=29) collected from two continents by analyzing 2.2 billion next-generation sequencing reads derived from both DNA and RNA. Among other virus families, we found sequences from members of the Picornaviridae to be abundant in the microbiome of all the samples. Here we describe the diversity of the picornavirus-like contigs including near-full-length genomes closely related to the Boone cardiovirus and Theiler's encephalomyelitis virus. From this study, we conclude that picornaviruses within R. norvegicus are more diverse than previously recognized. The virome of R. norvegicus should be investigated further to assess the full potential for zoonotic virus transmission.

dc.publisherNature Publishing Group
dc.titleHigh diversity of picornaviruses in rats from different continents revealed by deep sequencing
dc.typeJournal Article
dcterms.source.titleEmerging Microbes and Infections

This open access article is distributed under the Creative Commons license

curtin.departmentDepartment of Environment and Agriculture
curtin.accessStatusOpen access

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