Higher free thyroxine levels are associated with all-cause mortality in euthyroid older men: The Health in Men Study
MetadataShow full item record
Objective: Thyroid dysfunction predicts poorer health outcomes, but the relationship between thyroid hormone levels within the reference range and mortality in older adults remains unclear. In this study, we examined the associations between the concentrations of free thyroxine (FT4) and TSH and allcause mortality in older men without thyroid disease. Subjects and methods: We performed a longitudinal study in community-dwelling men aged 70-89 years. Men with thyroid disease or taking thyroid-related medications were excluded. Baseline FT4 and TSH levels were assayed. Incident deaths were ascertained using data linkage. Results: There were 3885 men without thyroid disease followed for (meanGS.D.) 6.4G1.5 years, during which time 837 had died (21.5%). Men who had died had higher baseline FT4 levels (16.2G2.3 vs 15.8G2.1 pmol/l, P!0.001), but comparable TSH levels (2.4G1.5 vs 2.3G1.5 mIU/l, PZ0.250). After accounting for age, smoking, physical factors and medical comorbidities, higher circulating FT4 levels predicted all-cause mortality (quartile Q4 vs quartiles Q1-Q3: FT4 levelsR17.32 vs!17.32 pmol/l: adjusted hazard ratio (HR)Z1.19, 95% CIZ1.02-1.39, PZ0.025). TSH levels did not predict mortality. After excluding men with subclinical hyperthyroidism or hypothyroidism, there were 3442 men and 737 who had died (21.4%). In these men, higher FT4 levels remained independently associated with all-cause mortality (quartile Q4 vs quartiles Q1-Q3: adjusted HRZ1.19, 95% CIZ1.02-1.41, PZ0.032). Conclusions: Higher FT4 levels are associated with all-cause mortality in euthyroid older men, independently of conventional risk factors and medical comorbidities. Additional research is needed to determine whether or not this relationship is causal and to clarify the utility of thyroid function testing to stratify mortality risk in ageing men. © 2013 European Society of Endocrinology.
Showing items related by title, author, creator and subject.
In older men an optimal plasma testosterone is associated with reduced all-cause mortality and higher dihydrotestosterone with reduced ischemic heart disease mortality, while estradiol levels do not predict mortalityYeap, B.; Alfonso, Helman; Paul Chubb, S.; Handelsman, D.; Hankey, G.; Almeida, O.; Golledge, J.; Norman, P.; Flicker, L. (2014)Context: Testosterone (T) levels decline with age and lower T has been associated with increased mortality in aging men. However, the associations of its metabolites, dihydrotestosterone (DHT) and estradiol (E2), with ...
Smoking-associated DNA methylation biomarkers and their predictive value for all-cause and cardiovascular mortalityZhang, Y.; Schöttker, B.; Florath, Ines; Stock, C.; Butterbach, K.; Holleczek, B.; Mons, U.; Brenner, H. (2016)Background: With epigenome-wide mapping of DNA methylation, a number of novel smoking-associated loci have been identified. Objectives: We aimed to assess dose–response relationships of methylation at the top hits from ...
Lower plasma testosterone or dihydrotestosterone, but not estradiol, is associated with symptoms of intermittent claudication in older menYeap, B.; Alfonso, Helman; Chubb, S.; Handelsman, D.; Hankey, G.; Golledge, J.; Flicker, L.; Norman, P. (2013)Objective In men, testosterone (T) levels decline with age, and lower T predicts all-cause and cardiovascular mortality. However, the associations of T and its metabolites, dihydrotestosterone (DHT) and estradiol (E2), ...