Myopia is associated with lower vitamin D status in young adults
MetadataShow full item record
Purpose: To investigate the association between serum vitamin D levels and myopia in young adults. Methods: A total of 946 individuals participating in the 20-year follow-up of the Western Australian Pregnancy Cohort (Raine) Study were included in this study. Ethnicity, parental myopia, and education status were ascertained by self-reported questionnaire. A comprehensive ophthalmic examination was performed, including postcycloplegic autorefraction and conjunctival UV autofluorescence photography. Serum 25-hydroxyvitamin D3 (25(OH)D3) concentrations were determined using mass spectrometry. The association between serum 25(OH)D3 concentrations and prevalent myopia was determined using multivariable logistic regression. Myopia was defined as mean spherical equivalent ≤ −0.5 diopters. Results: Of the 946 participants, 221 (23.4%) had myopia (n = 725 nonmyopic). Myopic subjects had lower serum 25(OH)D3 concentrations compared to nonmyopic participants (median 67.6 vs. 72.5 nmol, P = 0.003). In univariable analysis, lower serum 25(OH)D3 concentration was associated with higher risk of having myopia (odds ratio [OR] for <50 vs. ≥50 nmol/L: 2.63; confidence interval [95% CI] 1.71–4.05; P < 0.001). This association persisted after adjustment for potential confounders, including age, sex, ethnicity, parental myopia, education status, and ocular sun-exposure biomarker score (adjusted OR 2.07; 95% CI 1.29–3.32; P = 0.002).Conclusions: Myopic participants had significantly lower 25(OH)D3 concentrations. The prevalence of myopia was significantly higher in individuals with vitamin D deficiency compared to the individuals with sufficient levels. Longitudinal studies are warranted to investigate whether higher serum 25(OH)D3 concentration is protective against myopia or whether it is acting as a proxy for some other biologically effective consequence of sun exposure.
Showing items related by title, author, creator and subject.
Vitamin D status and predictors of serum 25-hydroxyvitamin D concentrations in Western Australian adolescentsBlack, Lucinda; Jacoby, P.; Burrows, S.; Oddy, W.; Beilin, L.; She Ping-Delfos, W.; Marshall, C.; Holt, P.; Hart, P.; Mori, Takeshi (2014)Despite the importance of skeletal growth during adolescence, there is limited research reporting vitamin D status and its predictors in adolescents. Using prospective data from the Western Australian Pregnancy Cohort ...
Differential nitric oxide levels in the blood and skeletal muscle of Type 2 diabetic subjects may be consequence of adiposity: a preliminary study.Krause, M.; Rodrigues-Krause, J.; O'Hagan, C.; De Vito, G.; Boreham, C.; Susta, D.; Newsholme, Philip; Murphy, C. (2012)Background and Aims: Nitric oxide (NO) exerts key regulatory functions including vasodilation and glucose uptake. Thus reduced NO levels are associated with insulin resistance and hypertension. In this preliminary work ...
Effects of long-term antioxidant supplementation and association of serum antioxidant concentrations with risk of metabolic syndrome in adultsCzernichow, S.; Vergnaud, A.; Galan, P.; Arnaud, J.; Favier, A.; Faure, H.; Huxley, Rachel; Hercberg, S.; Ahluwalia, N. (2009)Background: Limited observational evidence suggests lower antioxidant concentrations in individuals with the metabolic syndrome (MetS); few randomized controlled trials have addressed the effect of multiple antioxidants ...