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Hepatocellular carcinoma occurs most commonly in the setting of cirrhosis, where the annual rate of cancer development approximates 3-7%. Most cases arise in the setting of impaired liver regeneration combined with chronic inflammation and fibrosis. Liver progenitor cells play an important role in cell renewal processes in the liver in the setting of chronic injury and have recently emerged as potential candidates in the carcinogenic pathway. There are two main hypotheses which have been proposed to explain hepatocellular carcinogenesis, namely the de-differentiation and the maturation arrest hypotheses. Understanding the carcinogenic pathways and the role of liver progenitor cells will provide greater understanding and novel approaches to preventative strategies.
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Serum marker of inflammasome activity correlates with liver injury in nonalcoholic fatty liver disease and is influenced by genetic polymorphismsAdams, L.; Wree, A.; Melton, P.; Jeffrey, G.; Ching, H.; de Boer, B.; Olynyk, J.; Ayonrinde, O.; Mori, T.; Beilin, L.; Price, Patricia; Pennell, C.; Eslam, M.; George, J.; Feldstein, A. (2015)Background and Aims: The NLRP3 inflammasome has been implicated in the pathogenesis of liver injury in nonalcoholic fatty liver disease (NAFLD). In humans, mutations of Nlrp3 have functional consequences and result in ...
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Carlessi, Rodrigo; Lemos, N.; Dias, A.; Brondani, L.; Oliveira, J.; Bauer, A.; Leitão, C.; Crispim, D. (2015)The majority of liver grafts destined for transplantation originate from brain dead donors. However, significantly better posttransplantation outcomes are achieved when organs from living donors are used, suggesting that ...