Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Liver carcinogenesis

    Access Status
    Fulltext not available
    Authors
    Tirnitz-Parker, Janina
    Olynyk, John
    Date
    2009
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Tirnitz-Parker, Janina and Olynyk, John. 2009. Liver carcinogenesis. Cancer Forum. 33 (2): pp. 93-97.
    Source Title
    Cancer Forum
    Additional URLs
    http://www.cancerforum.org.au/Issues/2009/July/Forum/Liver_carcinogenesis.htm
    ISSN
    0311306X
    URI
    http://hdl.handle.net/20.500.11937/26453
    Collection
    • Curtin Research Publications
    Abstract

    Hepatocellular carcinoma occurs most commonly in the setting of cirrhosis, where the annual rate of cancer development approximates 3-7%. Most cases arise in the setting of impaired liver regeneration combined with chronic inflammation and fibrosis. Liver progenitor cells play an important role in cell renewal processes in the liver in the setting of chronic injury and have recently emerged as potential candidates in the carcinogenic pathway. There are two main hypotheses which have been proposed to explain hepatocellular carcinogenesis, namely the de-differentiation and the maturation arrest hypotheses. Understanding the carcinogenic pathways and the role of liver progenitor cells will provide greater understanding and novel approaches to preventative strategies.

    Related items

    Showing items related by title, author, creator and subject.

    • Serum marker of inflammasome activity correlates with liver injury in nonalcoholic fatty liver disease and is influenced by genetic polymorphisms
      Adams, L.; Wree, A.; Melton, P.; Jeffrey, G.; Ching, H.; de Boer, B.; Olynyk, J.; Ayonrinde, O.; Mori, T.; Beilin, L.; Price, Patricia; Pennell, C.; Eslam, M.; George, J.; Feldstein, A. (2015)
      Background and Aims: The NLRP3 inflammasome has been implicated in the pathogenesis of liver injury in nonalcoholic fatty liver disease (NAFLD). In humans, mutations of Nlrp3 have functional consequences and result in ...
    • Metabolic enzymes and mixed-function oxygenase (MFO) system in pink snapper (Pagrus auratus): biochemical and histological relationships
      Tugiyono (2001)
      The environmental health of aquatic ecosystems depends amongst others, on the chemical pollution coming from activities in the catchment's area. In the Swan River Estuary, Western Australia, the chemical pollutants of ...
    • Exendin-4 attenuates brain death-induced liver damage in the rat
      Carlessi, Rodrigo; Lemos, N.; Dias, A.; Brondani, L.; Oliveira, J.; Bauer, A.; Leitão, C.; Crispim, D. (2015)
      The majority of liver grafts destined for transplantation originate from brain dead donors. However, significantly better posttransplantation outcomes are achieved when organs from living donors are used, suggesting that ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.