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    Validation of a suite of biomarkers of fish health in the tropical bioindicator species, tambaqui (Colossoma macropomum)

    26722.pdf (545.2Kb)
    Access Status
    Open access
    Authors
    Sadauskas-Henrique, H.
    Duarte, R.
    Gagnon, Marthe Monique
    Almeida-Val, V.
    Date
    2017
    Type
    Journal Article
    
    Metadata
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    Citation
    Sadauskas-Henrique, H. and Duarte, R. and Gagnon, M.M. and Almeida-Val, V. 2017. Validation of a suite of biomarkers of fish health in the tropical bioindicator species, tambaqui (Colossoma macropomum). Ecological Indicators. 73: pp. 443-451.
    Source Title
    Ecological Indicators
    DOI
    10.1016/j.ecolind.2016.10.010
    ISSN
    1470-160X
    School
    Department of Environment and Agriculture
    URI
    http://hdl.handle.net/20.500.11937/26722
    Collection
    • Curtin Research Publications
    Abstract

    Here we explore the dose-dependent response of the tropical fish tambaqui (Colossoma macropomum) to intraperitoneal injection of benzo[a]pyrene (BaP) at doses of 0 (carrier control), 1, 10, 100 and 1000 µmolar BaP Kg-1 Hepatic ethoxyresorufin-O-deethylase (EROD) activity showed a bell-shaped dose-dependent response curve, where the highest injected BaP dose caused enzyme inactivation. Activities of hepatic catalase (CAT) and superoxide dismutase (SOD) increased at the highest dose relative to the carrier control group. Lipid peroxidation (LPO), serum-sorbitol dehydrogenase (s-SDH) and DNA damage in blood cells were higher for all BaP doses when compared to the carrier control group. At high dosage, the production of BaP metabolites was paralleled by induced activity of the antioxidant enzyme SOD, and high levels of DNA damage in blood cells. In a similar way, high LPO was concomitant to elevated s-SDH in the bloodstream, suggesting that lipid peroxidation caused the loss of membrane integrity and leakage of s-SDH from hepatocytes into the bloodstream. These biomarkers were also positively co-correlated. The results demonstrate the potential use of a suite of biomarkers for tambaqui living in contaminated tropical aquatic environments. In particular, we recommend the analysis of DNA damage in blood cells, as this was highly correlated with all other biomarkers. © 2016 Elsevier Ltd

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