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Characterization of the Electrochemical Behavior of Gastrointestinal Fluids Using a Multielectrode Sensor Probe

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Authors
Twomey, K.
Alvarez de Eulate, E.
Marchesi, J.
Kolida, S.
Gibson, G.
Arrigan, Damien
Ogurtsov, V.
Date
2011
Type
Journal Article

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Twomey, Karen and Alvarez de Eulate, Eva and Marchesi, Julian and Kolida, Sofia and Gibson, Glenn and Arrigan, Damien and Ogurtsov, Vladimir. 2011. Characterization of the Electrochemical Behavior of Gastrointestinal Fluids Using a Multielectrode Sensor Probe. IEEE Transactions on Biomedical Engineering. 58 (9): pp. 2521-2527.
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IEEE Transactions on Biomedical Engineering
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Department of Applied Chemistry
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Abstract

A characterization of gastrointestinal fluids has been performed by means of an electrochemical sensor that has potential for clinical in vivo and in vitro monitoring applications. The sensor comprised a three-electrode cell with a counter, reference, and four working electrodes, Au, Pt, Ir, and Rh. Cyclic voltammetry was used to obtain chemical information from faecal water (in vitro) and gut model (in vivo) fluids. Stable voltammetric responses were obtained for both fluids at these noble metal workingelectrodes. The responses differed in shape that demonstrated the discrimination capability and the potential for practical use as a tool for gastrointestinal fluid investigation. The analysis of the stabilityprofiles in faecal water over a 14-h duration has indicated a possible adsorptionmechanism with the formation of a biolayer on the sensor surface. The stability in gut model fluids over a 42-h durationhas demonstrated a more stable profile, but themechanisms involved are more complicated to determine.