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dc.contributor.authorEbert, J.
dc.contributor.authorSmith, Anne
dc.contributor.authorFallon, M.
dc.contributor.authorWood, D.
dc.contributor.authorAckland, T.
dc.identifier.citationEbert, J. and Smith, A. and Fallon, M. and Wood, D. and Ackland, T. 2014. Correlation between clinical and radiological outcomes after matrix-induced autologous chondrocyte implantation in the femoral condyles. The American Journal of Sports Medicine. 42 (8): pp. 1857-1864.

Background: Matrix-induced autologous chondrocyte implantation (MACI) is an established technique for the repair of knee chondral defects, although the correlation between clinical and radiological outcomes after surgery is poorly understood.Purpose: To determine the correlation between clinical and radiological outcomes throughout the postoperative timeline to 5 years after MACI.Study Design: Cohort study (diagnosis); Level of evidence, 3.Methods: This retrospective study was undertaken in 83 patients (53 male, 30 female) with complete clinical and radiological follow- up at 1, 2, and 5 years after MACI. The mean age of patients was 38.9 years (range, 13-62 years), with a mean body mass index (BMI) of 26.6 kg/m2 (range, 16.8-34.8 kg/m2), mean defect size of 3.3 cm2 (range, 1-9 cm2), and mean preoperative duration of symptoms of 9.2 years (range, 1-46 years). Patients indicated for MACI in this follow-up were 13 to 65 years of age, although they were excluded if they had a BMI .35 kg/m2, had undergone prior extensive meniscectomy, or had ongoing progressive inflammatory arthritis. Patients were assessed clinically using the Knee Injury and Osteoarthritis Outcome Score (KOOS). Magnetic resonance imaging (MRI) was used to evaluate the graft using a 1.5-T or 3-T clinical scanner; the MRI assessment included8 parameters of graft repair (infill, signal intensity, border integration, surface contour, structure, subchondral lamina, subchondral bone, and effusion) based on the magnetic resonance observation of cartilage repair tissue (MOCART) score as well as an MRI composite score. The degree of an association between the MRI parameters and the KOOS subscales at each postoperative timepoint was assessed with the Spearman correlation coefficient (SCC), and significance was determined at P\.05. Ethics approval was obtained from the appropriate hospital and university Human Research Ethics Committees, and informed consent was gathered from all patients.Results: The only MRI parameter displaying consistent evidence of an association with the KOOS subscales was effusion, with a pattern of increasing strength of correlations over time and statistically significant associations at 5 years with KOOS-Pain (SCC, 0.25; P = .020), KOOS–Activities of Daily Living (SCC, 0.26; P = .018), and KOOS-Sport (SCC, 0.32; P = .003). Apart from a significantcorrelation between subchondral lamina and KOOS-Sport at 1 year (SCC, 0.27; P = .016), no further significant findings were observed.Conclusion: Apart from some consistent evidence of an association between the KOOS and effusion, this analysis demonstrated a limited correlative capacity between clinical and radiological outcomes up to 5 years after surgery.

dc.publisherSage Publications Inc
dc.subjectmatrix-induced autologous chondrocyte implantation
dc.subjectradiological outcome
dc.subjectmagnetic resonance imaging
dc.subjectclinical outcome
dc.subjectpostoperative assessment
dc.titleCorrelation between clinical and radiological outcomes after matrix-induced autologous chondrocyte implantation in the femoral condyles
dc.typeJournal Article
dcterms.source.issn0363 5465
dcterms.source.titleThe American Journal of Sports Medicine
curtin.departmentSchool of Physiotherapy
curtin.accessStatusOpen access

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