Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    The impact of lost therapeutic benefit (LTB) in high-risk hypertensive patients: 2-Year follow-up data from the australian REACH registry

    Access Status
    Open access via publisher
    Authors
    Ademi, Z.
    Huq, M.
    Liew, D.
    Steg, P.
    Bhatt, D.
    Nelson, M.
    Reid, Christopher
    Date
    2013
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Ademi, Z. and Huq, M. and Liew, D. and Steg, P. and Bhatt, D. and Nelson, M. and Reid, C. 2013. The impact of lost therapeutic benefit (LTB) in high-risk hypertensive patients: 2-Year follow-up data from the australian REACH registry. Cardiovascular Therapeutics. 31 (6): pp. 370-376.
    Source Title
    Cardiovascular Therapeutics
    DOI
    10.1111/1755-5922.12034
    ISSN
    1755-5914
    School
    Department of Health Policy and Management
    URI
    http://hdl.handle.net/20.500.11937/26851
    Collection
    • Curtin Research Publications
    Abstract

    Objective: The aim of the study is to determine the extent of lost therapeutic benefit (LTB) in the hypertensive patients, and to determine the relationship between the presence of LTB and clinical outcomes. Methods: Prospective-cohort study of n = 2856 patients with or at high risk of atherothrombosis. LTB was calculated as the proportion of patients receiving blood pressure medication who were not attaining guideline blood pressure (BP) control targets (<140/90 mmHg). Logistic regression analysis was performed to identify predictors of LTB at baseline, and propensity score matching (PSM) was undertaken to estimate the treatment effects by matching case LTB and control non-LTB cohorts based on the nearest neighbor matching. Results: Of the total sample of 2856, 45.6% had uncontrolled BP, and LTB was present in 46.7% patients. The likelihood of LTB was less in males (OR = 0.78 [95% CI; 0.64-0.97]), and those with a previous myocardial infarction (OR = 0.66 [0.53-0.81]) or heart failure (OR = 0.58 [0.42-0.82]). LTB was more common in those with diabetes (OR = 1.44 [1.16-1.79]), aged >65 years (OR = 1.36 [1.06-1.75]) and having an ABI < 0.09 in either leg at rest (OR = 1.30 [1.02-1.75]). Following PSM, the combination of ischemic events (55-64 age category) was more likely to occur in the LTB compared with non-LTB group (4.38% and 0.68%, respectively [P = 0.046]). Conclusion: Presence of HF, previous MI and being male decreased the likelihood of LTB, while presence of diabetes, age > 65 and ABI < 0.09 increased the risk of LTB. Patients with LTB in age category 55-64 had higher incidence of vascular events compared with those with non-LTB. © 2013 John Wiley & Sons Ltd.

    Related items

    Showing items related by title, author, creator and subject.

    • The phenomenon of patient participation in their nursing care : a grounded theory study.
      Henderson, Saraswathy (1998)
      In recent times there has been an emphasis on patients participating in their own nursing care. Studies have demonstrated that when patients participate in their own care, they experience positive outcomes, such as greater ...
    • Experiences of cancer patients in a patient navigation program: a qualitative systematic review.
      Tan, C.; Wilson, S.; McConigley, Ruth (2015)
      BACKGROUND: A patient navigation program is a model of care which entails trained personnel providing individualized and assistive care to adult oncology patients to help the patients overcome barriers. A further aim of ...
    • Alcohol consumption, smoking and lifestyle characteristics for Japanese patients with chronic obstructive pulmonary disease
      Hirayama, Fumi (2008)
      This thesis investigated lifestyle characteristics including cigarette smoking, alcohol consumption, dietary supplements intake, physical activity, and urinary incontinence status for Japanese patients with chronic ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.