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    Low stromal Foxp3+ regulatory T-cell density is associated with complete response to neoadjuvant chemoradiotherapy in rectal cancer

    Access Status
    Open access via publisher
    Authors
    McCoy, M.
    Hemmings, C.
    Miller, T.
    Austin, S.
    Bulsara, M.
    Zeps, Nikolajs
    Nowak, A.
    Lake, R.
    Platell, C.
    Date
    2015
    Type
    Journal Article
    
    Metadata
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    Citation
    McCoy, M. and Hemmings, C. and Miller, T. and Austin, S. and Bulsara, M. and Zeps, N. and Nowak, A. et al. 2015. Low stromal Foxp3+ regulatory T-cell density is associated with complete response to neoadjuvant chemoradiotherapy in rectal cancer. British Journal of Cancer.
    Source Title
    British Journal of Cancer
    DOI
    10.1038/bjc.2015.427
    ISSN
    0007-0920
    URI
    http://hdl.handle.net/20.500.11937/27135
    Collection
    • Curtin Research Publications
    Abstract

    © 2015 Cancer Research UK Background:Foxp3+ regulatory T cells (Tregs) play a vital role in preventing autoimmunity, but also suppress antitumour immune responses. Tumour infiltration by Tregs has strong prognostic significance in colorectal cancer, and accumulating evidence suggests that chemotherapy and radiotherapy efficacy has an immune-mediated component. Whether Tregs play an inhibitory role in chemoradiotherapy (CRT) response in rectal cancer remains unknown.Methods:Foxp3+, CD3+, CD4+, CD8+ and IL-17+ cell density in post-CRT surgical samples from 128 patients with rectal cancer was assessed by immunohistochemistry. The relationship between T-cell subset densities and clinical outcome (tumour regression and survival) was evaluated.Results:Stromal Foxp3+ cell density was strongly associated with tumour regression grade (P=0.0006). A low stromal Foxp3+ cell density was observed in 84% of patients who had a pathologic complete response (pCR) compared with 41% of patients who did not (OR: 7.56, P=0.0005; OR: 5.27, P=0.006 after adjustment for presurgery clinical factors). Low stromal Foxp3+ cell density was also associated with improved recurrence-free survival (HR: 0.46, P=0.03), although not independent of tumour regression grade.Conclusions:Regulatory T cells in the tumour microenvironment may inhibit response to neoadjuvant CRT and may represent a therapeutic target in rectal cancer.British Journal of Cancer advance online publication 8 December 2015. doi:10.1038/bjc.2015.427 www.bjcancer.com.

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