Facile synthesis, ex-vivo and in vitro screening of 3-sulfonamide derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxy lic acid piperidin-1-ylamide (SR141716) a potent CB1 receptor antagonist
| dc.contributor.author | Kumar Srivastava, B. | |
| dc.contributor.author | Soni, R. | |
| dc.contributor.author | Patel, J. | |
| dc.contributor.author | Jha, S. | |
| dc.contributor.author | Shedage, S. | |
| dc.contributor.author | Gandhi, Neha | |
| dc.contributor.author | Sairam, K. | |
| dc.contributor.author | Pawar, V. | |
| dc.contributor.author | Sadhwani, N. | |
| dc.contributor.author | Mitra, P. | |
| dc.contributor.author | Jain, M. | |
| dc.contributor.author | Patel, P. | |
| dc.date.accessioned | 2017-01-30T12:58:06Z | |
| dc.date.available | 2017-01-30T12:58:06Z | |
| dc.date.created | 2016-09-12T08:36:25Z | |
| dc.date.issued | 2008 | |
| dc.identifier.citation | Kumar Srivastava, B. and Soni, R. and Patel, J. and Jha, S. and Shedage, S. and Gandhi, N. and Sairam, K. et al. 2008. Facile synthesis, ex-vivo and in vitro screening of 3-sulfonamide derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxy lic acid piperidin-1-ylamide (SR141716) a potent CB1 receptor antagonist. Bioorganic & Medicinal Chemistry Letters. 18 (14): pp. 3882-3886. | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11937/27282 | |
| dc.identifier.doi | 10.1016/j.bmcl.2008.06.045 | |
| dc.description.abstract |
Facile synthesis of biaryl pyrazole sulfonamide derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxy lic acid piperidin-1-ylamide (SR141716, 1) and an investigation of the effect of replacement of the -CO group in the compound 1 by the -SO2 group in the aminopiperidine region is reported. Primary ex-vivo pharmacological testing and in vitro screening of sulfonamide derivative 2 showed the loss of CB1 receptor antagonism. © 2008 Elsevier Ltd. All rights reserved. | |
| dc.publisher | Pergamon | |
| dc.title | Facile synthesis, ex-vivo and in vitro screening of 3-sulfonamide derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxy lic acid piperidin-1-ylamide (SR141716) a potent CB1 receptor antagonist | |
| dc.type | Journal Article | |
| dcterms.source.volume | 18 | |
| dcterms.source.number | 14 | |
| dcterms.source.startPage | 3882 | |
| dcterms.source.endPage | 3886 | |
| dcterms.source.issn | 0960-894X | |
| dcterms.source.title | Bioorganic & Medicinal Chemistry Letters | |
| curtin.department | School of Biomedical Sciences | |
| curtin.accessStatus | Fulltext not available |
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