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    Sedentary time and cardio-metabolic biomarkers in US adults: NHANES 2003-06

    Access Status
    Open access via publisher
    Authors
    Healy, Genevieve
    Matthews, C.
    Dunstan, D.
    Winkler, E.
    Owen, N.
    Date
    2011
    Type
    Journal Article
    
    Metadata
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    Citation
    Healy, G. and Matthews, C. and Dunstan, D. and Winkler, E. and Owen, N. 2011. Sedentary time and cardio-metabolic biomarkers in US adults: NHANES 2003-06. European Heart Journal. 32 (5): pp. 590-597.
    Source Title
    European Heart Journal
    DOI
    10.1093/eurheartj/ehq451
    ISSN
    0195-668X
    School
    School of Physiotherapy and Exercise Science
    URI
    http://hdl.handle.net/20.500.11937/27490
    Collection
    • Curtin Research Publications
    Abstract

    Aims: Prolonged sedentary time is ubiquitous in developed economies and is associated with an adverse cardio-metabolic risk profile and premature mortality. This study examined the associations of objectively assessed sedentary time and breaks (interruptions) in sedentary time with continuous cardio-metabolic and inflammatory risk biomarkers, and whether these associations varied by sex, age, and/or race/ethnicity. Methods and results: Cross-sectional analyses with 4757 participants (≥20 years) from the 2003/04 and 2005/06 US National Health and Nutrition Examination Survey (NHANES). An Actigraph accelerometer was used to derive sedentary time [<100 counts per minute (cpm)] and breaks in sedentary time. Independent of potential confounders, including moderate-to-vigorous exercise, detrimental linear associations (P for trends <0.05) of sedentary time with waist circumference, HDL-cholesterol, C-reactive protein, triglycerides, insulin, HOMA-B, and HOMA-S were observed. Independent of potential confounders and sedentary time, breaks were beneficially associated with waist circumference and C-reactive protein (P for trends <0.05).There was limited evidence of meaningful differences in associations with biomarkers by age, sex, or race/ethnicity. Notable exceptions were sex-differences in the associations of sedentary time and breaks with HDL-cholesterol, and race/ethnicity differences in the association of sedentary time with waist circumference with associations detrimental in non-Hispanic whites, null in Mexican Americans, and beneficial in non-Hispanic blacks. Conclusion: These are the first population-representative findings on the deleterious associations of prolonged sedentary time with cardio-metabolic and inflammatory biomarkers. The findings suggest that clinical communications and preventive health messages on reducing and breaking up sedentary time may be beneficial for cardiovascular disease risk.

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