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    Prediction of peri-operative adverse respiratory events in children: the role of exhaled nitric oxide

    Access Status
    Open access via publisher
    Authors
    Ramgolam, A.
    Hall, G.
    Zhang, Guicheng
    Hegarty, M.
    von Ungern-Sternberg, B.
    Date
    2015
    Type
    Journal Article
    
    Metadata
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    Citation
    Ramgolam, A. and Hall, G. and Zhang, G. and Hegarty, M. and von Ungern-Sternberg, B. 2015. Prediction of peri-operative adverse respiratory events in children: the role of exhaled nitric oxide. Anaesthesia. 70 (10): pp. 1160-1164.
    Source Title
    Anaesthesia
    DOI
    10.1111/anae.13123
    ISSN
    0003-2409
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/27758
    Collection
    • Curtin Research Publications
    Abstract

    Increased levels of exhaled nitric oxide (eNO) may be a more objective predictor in identifying children at higher risk of peri-operative adverse respiratory events than the presence of risk factors such as recent cold or wheeze. Children with either none or ≥ 2 risk factors had eNO measured before surgery and any peri-operative adverse respiratory events were recorded. We found that an elevated eNO level was only predictive of adverse respiratory events in children with ≥ 2 risk factors (OR 2.96 (95% CI 1.48–5.93), p = 0.002). The presence of risk factors had a better predictive capability than a raised eNO level (OR 3.83 (95% CI 1.85–7.95), p < 0.001). The combination of both predictors did not improve the predictive capability for adverse respiratory events (OR 1.93 (95% CI 1.44–2.59), p < 0.001). We conclude that measuring eNO levels does not lead to improved prediction of adverse respiratory events and that, in routine clinical practice, an accurate history of risk factors remains the most appropriate tool for successfully identifying children at risk of peri-operative adverse respiratory events.

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