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    Pharmaceutical modulation of diffusion potentials at aqueous–aqueous boundaries under laminar flow conditions

    Access Status
    Fulltext not available
    Authors
    Collins, C.
    Strutwolf, J.
    Arrigan, Damien
    Date
    2011
    Type
    Journal Article
    
    Metadata
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    Citation
    Collins, Courtney J. and Strutwolf, Jorg and Arrigan, Damien W.M. 2011. Pharmaceutical modulation of diffusion potentials at aqueous–aqueous boundaries under laminar flow conditions. Electrophoresis. 32 (8): pp. 844-849.
    Source Title
    Electrophoresis
    DOI
    10.1002/elps.201000299
    ISSN
    01730835
    School
    Nanochemistry Research Institute (Research Institute)
    URI
    http://hdl.handle.net/20.500.11937/2782
    Collection
    • Curtin Research Publications
    Abstract

    In this work, the modulation of the diffusion potential formed at the microfluidic aqueous–aqueous boundary by a pharmaceutical substance is presented. Co-flowing aqueous streams in a microchannel were used to form the stable boundary between the streams. Measurement of the open circuit potential between two silver/silver chloride electrodes enabled the diffusion potential at the boundary to be determined, which is concentration dependent. Experimental results for protonated propranolol as well as tetrapropylammonium are presented. This concept may be useful as a strategy for the detection of drug substances.

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