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    Immunopathogenesis of hepatic flare in HIV/hepatitis b virus (Hbv)-coinfected individuals after the initiation of Hbv-active antiretroviral therapy

    Access Status
    Open access via publisher
    Authors
    Crane, M.
    Oliver, B.
    Matthews, G.
    Avihingsanon, A.
    Ubolyam, S.
    Markovska, V.
    Chang, J.
    Dore, G.
    Price, Patricia
    Visvanathan, K.
    French, M.
    Ruxrungtham, K.
    Lewin, S.
    Date
    2009
    Type
    Journal Article
    
    Metadata
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    Citation
    Crane, M. and Oliver, B. and Matthews, G. and Avihingsanon, A. and Ubolyam, S. and Markovska, V. and Chang, J. et al. 2009. Immunopathogenesis of hepatic flare in HIV/hepatitis b virus (Hbv)-coinfected individuals after the initiation of Hbv-active antiretroviral therapy. Journal of Infectious Diseases. 199 (7): pp. 974-981.
    Source Title
    Journal of Infectious Diseases
    DOI
    10.1086/597276
    ISSN
    0022-1899
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/27864
    Collection
    • Curtin Research Publications
    Abstract

    Background. The pathogenesis of and risk factors for hepatic flare (HF) after the initiation of hepatitis B virus (HBV)-active antiretroviral therapy (ART) in HIV/HBV-coinfected individuals is not well understood. Methods. We studied HF in ART-naive HIV/HBV-coinfected individuals in Thailand (n= 36) who were beginning HBV-active ART as part of a prospective clinical trial. HF was defined as an alanine aminotransferase (ALT) level-5 times the upper limit of normal or-200 IU/L higher than that at baseline. Immune mediators (interleukin [IL]-18, IL-2, IL-6, IL-8, IL-10, soluble CD26 [sCD26], sCD30, sCD8, CXCL-10, CCL-2, tumor necrosis factor-a, interferon [IFN]-?, and IFN-a) and activated NK cells were quantified. Results. HBV DNA and ALT levels at baseline were higher in patients with HF (n-8) than in patients without HF (n = 28) (P < .01). After the initiation of ART, CXCL-10 levels remained elevated in patients with HF but decreased in patients without HF (P = .01). sCD30 levels increased and were significantly higher at week 8 in patients with HF (P < .05). There was a positive correlation between levels of ALT and levels of CXCL-10, sCD30, CCL-2, and IL-18 at week 8 (the time of peak ALT level) but not at other time points. Conclusion. Elevated HBV DNA and ALT levels before the initiation of HBV-active ART are risk factors for HF. The pathogenesis of HF after the initiation of HBV-active ART is probably consistent with immune restoration disease. © 2009 by the Infectious Diseases Society of America.

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