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    Translational research for improving the care of familial hypercholesterolemia: The “ten countries study” and beyond

    241960_241960.pdf (788.7Kb)
    Access Status
    Open access
    Authors
    Watts, G.
    Ding, P.
    George, P.
    Hagger, Martin
    Hu, M.
    Lin, J.
    Khoo, K.
    Marais, A.
    Miida, T.
    Nawawi, H.
    Pang, J.
    Park, J.
    Gonzalez-Santos, L.
    Su, T.
    Truong, T.
    Santos, R.
    Soran, H.
    Yamashita, S.
    Tomlinson, B.
    Arikketh, D.
    Ashavaid, T.
    Atiqah, N.
    Balasubramaniam, S.
    Chan, D.
    Chang, N.
    Do, T.
    Zhao, D.
    Ellis, K.
    Han, K.
    Hardcastle, S.
    Jannes, C.
    Kassim, A.
    Ismail, Z.
    Kwok, S.
    Lam, C.
    Lansberg, P.
    Livingston, M.
    Mehta, M.
    Muir, L.
    Peng, H.
    Pereira, A.
    Rahman, T.
    Ramli, A.
    Rangarajan, N.
    Razak, S.
    Sijbrands, E.
    Sullivan, D.
    Shyong Tai, E.
    Tan, H.
    Verma, I.
    Wu, X.
    Date
    2016
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Watts, G. and Ding, P. and George, P. and Hagger, M. and Hu, M. and Lin, J. and Khoo, K. et al. 2016. Translational research for improving the care of familial hypercholesterolemia: The “ten countries study” and beyond. Journal of Atherosclerosis and Thrombosis. 23 (8): pp. 891-900.
    Source Title
    Journal of Atherosclerosis and Thrombosis
    DOI
    10.5551/jat.35949
    ISSN
    1340-3478
    School
    School of Psychology and Speech Pathology
    Remarks

    This open access article is distributed under the Creative Commons license https://creativecommons.org/licenses/by-nc-sa/4.0/

    URI
    http://hdl.handle.net/20.500.11937/28030
    Collection
    • Curtin Research Publications
    Abstract

    © 2016 Japan Atherosclerosis Society.Familial hypercholesterolemia (FH) is the most common and serious form of inherited hyperlipidaemia. Dominantly inherited with high penetrance, untreated FH leads to premature death from coronary artery disease due to accelerated atherosclerosis from birth. Despite its importance, there is still a major shortfall in awareness, detection and treatment of FH worldwide. International models of care for FH have recently been published, but their effective implementation requires the garnering of more knowledge about the condition. The “Ten Countries Study” aims to investigate diagnostic, epidemiological and service aspects, as well as physician practices and patient experiences of FH in several countries in the Asia-Pacific Region and the Southern Hemisphere. Five observational studies are being undertaken that will systematically investigate the following aspects of FH: the phenotypic predictors of low-density lipoprotein receptor mutations, the point prevalence in available community populations, current knowledge and clinical practices among primary care physicians, availability and utilisation of services and facilities, and patient perceptions and personal experiences of the condition. The information gathered will inform better clinical practice and will enable the development of country-specific models of care for FH.

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