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    A lumped-parameter model of the cerebrospinal system for investigating arterial-driven flow in posttraumatic syringomyelia

    Access Status
    Fulltext not available
    Authors
    Elliott, Novak
    Lockerby, D.
    Brodbelt, A.
    Date
    2011
    Type
    Journal Article
    
    Metadata
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    Citation
    Elliott, N.S.J. and Lockerby, D.A. and Brodbelt, A.R. 2011. A lumped-parameter model of the cerebrospinal system for investigating arterial-driven flow in posttraumatic syringomyelia. Medical Engineering & Physics. 33 (7): pp. 874-882.
    Source Title
    Medical Engineering & Physics
    DOI
    10.1016/j.medengphy.2010.07.009
    ISSN
    1350-4533
    School
    Department of Mechanical Engineering
    URI
    http://hdl.handle.net/20.500.11937/28111
    Collection
    • Curtin Research Publications
    Abstract

    Fluid transport in syringomyelia has remained enigmatic ever since the disease was first identified some three centuries ago. However, accumulating evidence in the last decade from animal studies implicates arterial pulsations in syrinx formation. In particular, it has been suggested that a phase difference between the pressure pulse in the spinal subarachnoid space and the perivascular spaces, due to a pathologically disturbed cerebrospinal fluid (CSF) or blood supply, could result in a net influx of CSF into the spinal cord (SC). A lumped-parameter model is developed of the cerebrospinal system to investigate this conjecture. It is found that although this phase-lag mechanism may operate, it requires the SC to have an intrinsic storage capacity due to the collapsibility of the contained venous reservoir. This net flux is associated with a higher mean pressure in the SC than the SSS which is maintained in the periodic steady state. According to our simulations the mechanical perturbations of arachnoiditis exacerbate the phase-lag effect, which may be partially alleviated by the presence of a posttraumatic syrinx and more completely by a syringo-subarachnoid shunt.

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