Curtin University Homepage
  • Library
  • FAQ
    • Log in

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    The Impact of Simvastatin on Pulmonary Effectors of Pseudomonas aeruginosa Infection

    Access Status
    Open access via publisher
    Authors
    Hennessy, E.
    O'Callaghan, J.
    Mooij, M.
    Legendre, C.
    Camacho-Vanegas, O.
    Camacho, S.
    Adams, C.
    Martignetti, J.
    O'Gara, Fergal
    Date
    2014
    Collection
    • Curtin Research Publications
    Type
    Journal Article
    Metadata
    Show full item record
    Abstract

    The statin family of cholesterol-lowering drugs is known to have pleiotropic properties which include anti-inflammatory and immunomodulatory effects. Statins exert their pleiotropic effects by altering expression of human immune regulators including pro-inflammatory cytokines. Previously we found that statins modulate virulence phenotypes of the human pathogen Pseudomonas aeruginosa, and sought to investigate if simvastatin could alter the host response to this organism in lung epithelial cells. Simvastatin increased the expression of the P. aeruginosa target genes KLF2, KLF6, IL-8 and CCL20.Furthermore, both simvastatin and P. aeruginosa induced alternative splicing of KLF6. The novel effect of simvastatin on wtKLF6 expression was found to be responsible for induction of the KLF6 regulated genes CCL20 and iNOS. Simvastatin also increased the adhesion of P. aeruginosa to host cells, without altering invasion or cytotoxicity. This study demonstrated that simvastatin had several novel effects on the pulmonary cellular immune response.

    Citation
    Hennessy, E. and O'Callaghan, J. and Mooij, M. and Legendre, C. and Camacho-Vanegas, O. and Camacho, S. and Adams, C. et al. 2014. The Impact of Simvastatin on Pulmonary Effectors of Pseudomonas aeruginosa Infection. PLoS ONE. 9 (7).
    Source Title
    PLoS ONE
    URI
    http://hdl.handle.net/20.500.11937/28253
    DOI
    10.1371/journal.pone.0102200
    Department
    School of Biomedical Sciences

    Related items

    Showing items related by title, author, creator and subject.

    • The Impact of Simvastatin on Pulmonary Effectors of Pseudomonas aeruginosa Infection
      Hennessy, E.; O'Callaghan, J.; Mooij, M.; Legendre, C.; Camacho-Vanegas, O.; Camacho, S.; Adams, C.; Martignetti, J.; O'Gara, Fergal (2014)
      The statin family of cholesterol-lowering drugs is known to have pleiotropic properties which include anti-inflammatory and immunomodulatory effects. Statins exert their pleiotropic effects by altering expression of human ...
    • Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: Evidence for non-canonical activation of RhoA and Rac1 GTPases
      Zhu, Y.; Casey, P.; Kumar, A.; Pervaiz, Shazib (2013)
      Although statins are known to inhibit proliferation and induce death in a number of cancer cell types, the mechanisms through which downregulation of the mevalonate (MVA) pathway activates death signaling remain poorly ...
    • Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases
      Zhu, Y.; Casey, P.; Kumar, Alan Prem; Pervaiz, S. (2013)
      Although statins are known to inhibit proliferation and induce death in a number of cancer cell types, the mechanisms through which downregulation of the mevalonate (MVA) pathway activates death signaling remain poorly ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorsTitlesSubjectsDocument TypesThis CollectionIssue DateAuthorsTitlesSubjectsDocument Types

    My Account

    Log in

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Connect with Curtin

    • 
    • 
    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Send FeedbackContact Us
    DSpace software copyright © 2002-2015  DuraSpace