Serum Ferritin and Nutritional Status: Insights From an Eating Disorders Clinic Population
MetadataShow full item record
Objective: To determine the relationship between serum ferritin and malnutrition in newly assessed patients at a paediatric eating disorders clinic. Design: This was a prospectively assessed clinical cohort study. Setting: Intake assessment clinic of a tertiary eating disorders service for children and adolescents. Methods: Clinical, anthropometric and laboratory features of children and adolescents were systematically measured. The relationship of serum ferritin to other clinical, anthropometric and laboratory measures was determined using linear regression. Results: A total of 121 female patients aged 9.5–17.6 years were included, with body mass index(BMI) z score -5.7 to 1.9 (median -1.3). Using multiple regression, serum ferritin was inversely associated with BMI z score (regression coefficient (ß)=-0.234, 95% CI -0.413 to -0.055) and serum insulin-like growth factor 1 (IGF-1) (ß=-0.476, 95% CI -0.884 to -0.068) and positively associated with alanine aminotransferase (ß=0.357, 95% CI 0.055 to 0.659, controlling for age, pubertal stage and serum iron).Conclusions: In malnourished adolescents with eating disorders increased serum ferritin is associated with lower BMI z score and serum IGF-1.
Showing items related by title, author, creator and subject.
Nadakkavukaran, I.; Gan, E.; Olynyk, John (2012)Hereditary haemochromatosis (HH) is a common autosomal recessive disorder of iron overload in Caucasian populations. Clinical manifestations usually occur in individuals homozygous for the C282Y mutation in the HFE gene ...
Balasubramanian, Shanthi; Carnagarin, Revathy; Arcot, Jagdeeshwaran Manjula; Subhashree, Subhashree (2013)Background: Protein glycation is a spontaneous reaction that is believed to play a key role in the pathogenesis of many clinical disorders. The glycation of proteins is enhanced by elevated glucose concentrations. The ...
Higher ferritin levels, but not serum iron or transferrin saturation, are associated with Type 2 diabetes mellitus in adult men and women free of genetic haemochromatosisYeap, B.; Divitini, M.; Gunton, J.; Olynyk, John; Beilby, J.; McQuillan, B.; Hung, J.; Knuiman, M. (2015)Context - Iron overload predisposes to diabetes and higher ferritin levels have been associated with diabetes. However, it is unclear whether ferritin reflects differences in iron-related parameters between diabetic and ...