Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Computational fluid dynamics analysis of the effect of simulated plaques in the left coronary artery: A preliminary study.

    183227_56591_chaichana.pdf (1.200Mb)
    Access Status
    Open access
    Authors
    Chaichana, T.
    Jewkes, James
    Sun, Zhonghua
    Date
    2011
    Type
    Conference Paper
    
    Metadata
    Show full item record
    Citation
    Chaichana, T. and Jewkes, J. and Sun, Z. 2011. Computational fluid dynamics analysis of the effect of simulated plaques in the left coronary artery: A preliminary study, in Chan, F., Marinova, D. and Anderssen, R.S. (ed), MODSIM2011: 19th International Congress on Modelling and Simulation, Dec 12-16 2011, pp. 510-515. Perth, WA: Modelling and Simulation Society of Australia and New Zealand.
    Source Title
    MODSIM 2011
    Source Conference
    19th International Congress on Modelling and Simulation
    Additional URLs
    http://www.mssanz.org.au/modsim2011/A7/chaichana.pdf
    ISBN
    978-0-9872143-1-7
    School
    Department of Imaging and Applied Physics
    Remarks

    Copyright © 2011 The Authors and MSSANZ

    URI
    http://hdl.handle.net/20.500.11937/28653
    Collection
    • Curtin Research Publications
    Abstract

    Background: Atherosclerosis is the most common cause of coronary artery disease which is formed by plaque presence inside the artery wall leading to blockage of the blood supply to the heart muscle. The mechanism of atherosclerotic development is dependent on the blood flow variations in the artery wall during cardiac cycles. Characterization of plaque components and investigation of the plaques with subsequent coronary artery stenosis and myocardial dysfunction has been extensively studied in the literature. However, little is known about the effect of plaques on hemodynamic changes to the coronary artery, to the best of our knowledge. Investigation of the position of plaques in the coronary artery and its corresponding regional hemodynamic effects will provide valuable information for prediction of the coronary artery disease progression. The aim of this study is to investigate the effect of simulated plaques in the left coronary artery using computational fluid dynamics. Methods: A left coronary artery model was generated based on a computed tomography data in a patient suspected of coronary artery disease. The model consists of the left main coronary artery, left anterior descending and left circumflex, together with side branches. Simulated coronary plaques were created and placed in the left main coronary artery and left anterior descending with a resultant lumen stenosis of more than 50%. The blood rheology and pulsatile velocity at the left coronary artery were applied to simulate the realistic physiological situation. A transient simulation was performed to demonstrate the hemodynamic changes during cardiac phases. The flow velocity pattern, wall shear stress and wall pressure were measured at peak systolic and middle diastolic phases in the models with and without presence of plaques.Results: Our results showed that the flow change due to the simulated coronary plaques demonstrated a large circulation region at the left coronary bifurcation, and the velocity through bifurcation was increased. In contrast, a smooth flow pattern was observed in the non-calcified regions and flow velocity was low at the bifurcation. Low wall pressure was present in the coronary artery with a simulated coronary plaque whereas there was high wall pressure in the normal coronary artery. The simulated plaques resulted in high wall shear stress when compared to the low wall shear stress present in the normal coronary artery. The simulated coronary plaques interfered with blood flow behavior which was demonstrated as a large region of disturbed flow at coronary bifurcation. Conclusion: We successfully simulated the coronary plaques in a realistic coronary model and the effect of plaques in different locations on subsequent hemodynamic changes. Our preliminary study is useful for further investigation of the development of atherosclerosis in patients with different cardiac risk factors.

    Related items

    Showing items related by title, author, creator and subject.

    • Haemodynamic evaluation of coronary artery plaques : prediction of coronary atherosclerosis and disease progression
      Chaichana, Thanapong (2012)
      Coronary artery disease is the leading cause of death in advanced countries. Coronary artery disease tends to develop at locations where disturbed flow patterns occur, such as the left coronary artery. Haemodynamic change ...
    • An investigation of correlation between left coronary bifurcation angle and hemodynamic changes in coronary stenosis by coronarycomputed tomography angiography-derived computational fluid dynamics
      Sun, Zhonghua; Chaichana, T. (2017)
      Background: To investigate the correlation between left coronary bifurcation angle and coronary stenosis as assessed by coronary computed tomography angiography (CCTA)-generated computational fluid dynamics (CFD) analysis ...
    • Computational fluid dynamics analysis of the effect of plaques in the left coronary artery
      Chaichana, T; Sun, Zhonghua; Jewkes, James (2012)
      This study was to investigate the hemodynamic effect of simulated plaques in left coronary artery models, which were generated from a sample patient’s data. Plaques were simulated and placed at the left main stem and the ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.