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    Bioprocess challenges to the isolation and purification of bioactive peptides

    Access Status
    Fulltext not available
    Authors
    Agyei, D.
    Ongkudon, C.
    Wei, C.
    Chan, A.
    Danquah, Michael
    Date
    2016
    Type
    Journal Article
    
    Metadata
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    Citation
    Agyei, D. and Ongkudon, C. and Wei, C. and Chan, A. and Danquah, M. 2016. Bioprocess challenges to the isolation and purification of bioactive peptides. Food and Bioproducts Processing. 98: pp. 244-256.
    Source Title
    Food and Bioproducts Processing
    DOI
    10.1016/j.fbp.2016.02.003
    ISSN
    0960-3085
    School
    Curtin Sarawak
    URI
    http://hdl.handle.net/20.500.11937/28679
    Collection
    • Curtin Research Publications
    Abstract

    Published by Elsevier B.V. All rights reserved. Food protein-derived bioactive peptides (BPs) have been reported to trigger certain physiological responses in the body, thereby influencing health positively. These peptides have attracted high research and consumer interests due to their huge potential of use in functional foods and other dietary interventions of disease control and health promotion. However, successful product development is limited by the fact that current manufacturing processes are either difficult to scale up, high in cost, or have the potential to affect the structure-activity properties of these peptides. To overcome these challenges, we have proposed in this review, the use of an integrated '-omics' approach comprising in silico analysis and '-omics' techniques (such as peptidomics) to respectively forecast and validate the biological and physico-chemical properties of the peptides. This information is then used for the rational design of suitable purification steps for peptides of interest. Downstream purification could also be undertaken by liquid chromatography using monolithic adsorbents physico-chemically engineered (using results of in silico analysis) for rapid isolation of peptides. By coupling the high throughput and predictive capability of '-omics' to the enhanced convective hydrodynamics of monolithic columns, it becomes feasible, even at preparative scale, to produce BPs that meet the requirements of high purity, potency, and cost-effectiveness.

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