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    Preparation of three-dimensional interconnected macroporous cellulosic hydrogels for soft tissue engineering

    Access Status
    Fulltext not available
    Authors
    Yue, Z.
    Wen, F.
    Gao, S.
    Ang, M.
    Pallathadka, P.
    Liu, Lihong
    Yu, H.
    Date
    2010
    Type
    Journal Article
    
    Metadata
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    Citation
    Yue, Z. and Wen, F. and Gao, S. and Ang, M. and Pallathadka, P. and Liu, L. and Yu, H. 2010. Preparation of three-dimensional interconnected macroporous cellulosic hydrogels for soft tissue engineering. Biomaterials. 31 (32): pp. 8141-8152.
    Source Title
    Biomaterials
    DOI
    10.1016/j.biomaterials.2010.07.059
    ISSN
    0142-9612
    School
    Department of Chemical Engineering
    URI
    http://hdl.handle.net/20.500.11937/28839
    Collection
    • Curtin Research Publications
    Abstract

    This work exploits the thermal responsive phase behavior of hydroxypropylcellulose to produce 3D interconnected macroporous hydrogels in aqueous environment. Hydroxypropylcellulose was modified with allyl isocyanate, and their temperature mediated phase behavior was studied as a function of degree of modification (DS). A derivative with a DS of 1.5 was selected for scaffold preparation. Its aqueous solutions were warmed up to trigger the formation of biphasic systems. Such state was then immobilized efficiently by ?-ray irradiated crosslinking. Lyophilization of the crosslinked hydrogels yielded 3D macroporous sponges. The re-hydrated gels demonstrate a combination of interconnected macroporosity, high water content and mechanical integrity to soft tissues. Cytocompatibility was demonstrated among various cell types, and in vivo biocompatibility test showed minimal inflammatory response within 12 weeks' subcutaneous implantation in mice. The potential applications of these macroporous hydrogels in tissue engineering are discussed. © 2010 Elsevier Ltd.

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