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    Study of morphologic response of chondrocytes to uniaxial compression of articular cartilage

    Access Status
    Fulltext not available
    Authors
    Wu, Ping
    Kirk, Brett
    Milne, N.
    Delaney, P.
    Date
    2008
    Type
    Conference Paper
    
    Metadata
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    Citation
    Wu, J.P. and Kirk, T.B. and Milne, N. and Delaney, P. 2008. Study of morphologic response of chondrocytes to uniaxial compression of articular cartilage, in A.Hierlemann (ed), IASTED International Conference on Biomedical Engineering 2008, Feb 13 2008, pp. 121-125. Innsbruck; Austria: ACTA Press.
    Source Title
    Proceedings of the 6th IASTED International Conference on Biomedical Engineering
    Source Conference
    IASTED International Conference on Biomedical Engineering 2008
    ISBN
    978-088986721-5
    School
    Department of Mechanical Engineering
    URI
    http://hdl.handle.net/20.500.11937/29124
    Collection
    • Curtin Research Publications
    Abstract

    Osteoarthritis is synonymous to the functional disorder of articular cartilage. Mechanical tests of articular cartilage offer a way to understand the tissue’s functionality and osteoarthritis. During normal activities, chondrocytes (cells) are indirectly exposed to varied mechanical compressions exerted on articular cartilage. Study of the morphological response of chondrocytes to the mechanical compressions exerted on articular cartilage offers understanding the physical integrity of chondrocytes, and initial physiological change of articular cartilage for detecting early osteoarthritis. Fibre optic confocal microscopy uses fibre optic imaging technologies to study the internal microstructure of bulk articular cartilage. The technologies have led to develop confocal arthroscopy for in vivo studying the cellular structure of articular cartilage. Using fibre optic laser confocal microscopy and a developed computer image analysis software, we studied the morphological response of the chondrocytes in the superficial and transitional zone to the uniaxial compression of articular cartilage at 0.25MPa and 0.5MPa. The results suggest that the mechanical compression exerted on articular cartilage caused morphological changes of the chondrocytes, which can be measured by the technique described in this study. The technique developed in this study shows potential to develop a methodology for in vivo studying the physiological integrity of chondrocyte and early osteoarthritis.

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