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    β-Amyloid or its precursor protein is found in epithelial cells of the small intestine and is stimulated by high-fat feeding

    Access Status
    Fulltext not available
    Authors
    Galloway, Susan
    Jian, Le
    Johnsen, R.
    Chew, Stewart
    Mamo, John
    Date
    2007
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Galloway, Susan and Jian, Le and Johnsen, Russell and Chew, Stewart and Mamo, John. 2007. β-Amyloid or its precursor protein is found in epithelial cells of the small intestine and is stimulated by high-fat feeding. Journal of Nutritional Biochemistry. 18 (4): pp. 279-284.
    Source Title
    Journal of Nutritional Biochemistry
    DOI
    10.1016/j.jnutbio.2006.07.003
    ISSN
    09552863
    Faculty
    Faculty of Health Sciences
    School of Public Health
    Remarks

    The link to the journal’s home page is: http://www.elsevier.com/wps/find/journaldescription.cws_home/525013/description#description

    Copyright © 2007 Elsevier Ltd. All rights reserved

    URI
    http://hdl.handle.net/20.500.11937/29323
    Collection
    • Curtin Research Publications
    Abstract

    In Alzheimer's disease (AD), β-amyloid (Aβ) is deposited in extracellular matrices, initiating an inflammatory response and compromising cellular integrity. Epidemiological evidence and studies in animal models provide strong evidence that high-saturated-fat and/or cholesterol-rich diets exacerbate cerebral amyloidosis, although the mechanisms for this are unclear. Aβ contains hydrophobic domains and is normally bound to lipid-associated chaperone proteins. In previous studies, we have put forward the notion that Aβ is a regulatory component of postprandial lipoproteins (i.e., chylomicrons) and that aberrations in kinetics may be a contributing risk factor for AD. To explore this further, in this study, we utilized an immunohistochemical approach to determine if Aβ or its precursor protein is expressed in epithelial cells of the small intestine — the site of chylomicron biogenesis. Wild-type mice were fed a low-fat or a high-fat dietary regime and sacrificed, and their small intestines were isolated. We found that, in mice fed low-fat chow, substantial Aβ/precursor protein was found exclusively in absorptive epithelial cells of the small intestine. In contrast, no Aβ/precursor protein was found in epithelial cells when mice were fasted for 65 h. In addition, we found that a high-fat feeding regime strongly stimulates epithelial cell Aβ/precursor protein concentration. Our findings are consistent with the notion that Aβ may serve as a regulatory apolipoprotein of postprandial lipoproteins.

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