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dc.contributor.authorRouxel, Thierry
dc.contributor.authorGraubert, Jonathan
dc.contributor.authorHane, James K.
dc.contributor.authorHoede, Claire
dc.contributor.authorVan de Wouw, Angela P.
dc.contributor.authorCouloux, Arnaud
dc.contributor.authorDominguez, Victoria
dc.contributor.authorAnthouard, Véronique
dc.contributor.authorBally, Pascal
dc.contributor.authorBourras, Salim
dc.contributor.authorCozijnsen, Anton J.
dc.contributor.authorCiuffetti, Lynda M.
dc.contributor.authorDegrave, Alexandre
dc.contributor.authorDilmaghani, Azita
dc.contributor.authorDuret, Laurent
dc.contributor.authorFudal, Isabelle
dc.contributor.authorGoodwin, Stephen B.
dc.contributor.authorGout, Lilian
dc.contributor.authorGlaser, Nicolas
dc.contributor.authorLinglin, Juliette
dc.contributor.authorKema, Gert H. J.
dc.contributor.authorLapalu, Nicolas
dc.contributor.authorLawrence, Christopher B.
dc.contributor.authorMay, Kim
dc.contributor.authorMeyer, Michel
dc.contributor.authorOllivier, Bénédicte
dc.contributor.authorPoulain, Julie
dc.contributor.authorSchoch, Conrad L.
dc.contributor.authorSimon, Adeline
dc.contributor.authorSpatafora, Joseph W.
dc.contributor.authorStachowiak, Anna
dc.contributor.authorTurgeon, B. Gillian
dc.contributor.authorTyler, Brett M.
dc.contributor.authorVincent, Delphine
dc.contributor.authorWeissenbach, Jean
dc.contributor.authorAmselem, Joëlle
dc.contributor.authorQuesneville, Hadi
dc.contributor.authorOliver, Richard P.
dc.contributor.authorWincker, Patrick
dc.contributor.authorBalesdent, Marie-Hélène
dc.contributor.authorHowlett, Barbara J.
dc.date.accessioned2017-01-30T13:12:46Z
dc.date.available2017-01-30T13:12:46Z
dc.date.created2012-03-04T20:00:46Z
dc.date.issued2011
dc.identifier.citationRouxel, Thierry and Grandaubert, Jonathan and Hane, James K. and Hoede, Claire and Van de Wouw, Angela P. and Couloux, Arnaud and Dominguez, Victoria et al. Effector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations. Nature Communications. 2: Article ID 202.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/29427
dc.identifier.doi10.1038/ncomms1189
dc.description.abstract

Fungi are of primary ecological, biotechnological and economic importance. Many fundamental biological processes that are shared by animals and fungi are studied in fungi due to their experimental tractability. Many fungi are pathogens or mutualists and are model systems to analyse effector genes and their mechanisms of diversification. In this study, we report the genome sequence of the phytopathogenic ascomycete Leptosphaeria maculans and characterize its repertoire of protein effectors. The L. maculans genome has an unusual bipartite structure with alternating distinct guanine and cytosine-equilibrated and adenine and thymine (AT)-rich blocks of homogenous nucleotide composition. The AT-rich blocks comprise one-third of the genome and contain effector genes and families of transposable elements, both of which are affected by repeat-induced point mutation, a fungal-specific genome defence mechanism. This genomic environment for effectors promotes rapid sequence diversification and underpins the evolutionary potential of the fungus to adapt rapidly to novel host-derived constraints.

dc.publisherMacmillan Publishers Limited
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subjectMolecular biology
dc.subjectMicrobiology
dc.subjectBioinformatics
dc.subjectBiological Sciences
dc.titleEffector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations
dc.typeJournal Article
dcterms.source.volume2
dcterms.source.number202
dcterms.source.startPage1
dcterms.source.endPage10
dcterms.source.issn20411723
dcterms.source.titleNature Communications
curtin.departmentDepartment of Environment and Agriculture
curtin.accessStatusOpen access


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