Show simple item record

dc.contributor.authorWarrier, Sudha
dc.contributor.authorMarimuthu, R.
dc.contributor.authorSekhar, S.
dc.contributor.authorBhuvanalakshmi, G.
dc.contributor.authorArfuso, Frank
dc.contributor.authorDas, A.
dc.contributor.authorBhonde, R.
dc.contributor.authorMartins, R.
dc.contributor.authorDharmarajan, Arunasalam
dc.date.accessioned2017-01-30T13:17:12Z
dc.date.available2017-01-30T13:17:12Z
dc.date.created2016-05-05T19:30:12Z
dc.date.issued2016
dc.identifier.citationWarrier, S. and Marimuthu, R. and Sekhar, S. and Bhuvanalakshmi, G. and Arfuso, F. and Das, A. and Bhonde, R. et al. 2016. SFRP-mediated Wnt sequestration as a potential therapeutic target for Alzheimer's disease. International Journal of Biochemistry and Cell Biology. 75: pp. 104-111.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/30058
dc.identifier.doi10.1016/j.biocel.2016.04.002
dc.description.abstract

The extracellular ligand, Wnt, and its receptors are involved in sign al transduction and play an important role in axis formation and neural development. In neurodegenerative disorders such as Alzheimer's disease (AD), a decrease of the intracellular Wnt effector, ß-catenin, has been linked to amyloid-ß-peptide-induced neurotoxicity. Despite this knowledge, targeting Wnt inhibitors as potential biomarkers has not been explored, and harnessing Wnt activators as therapeutic candidates remains largely not investigated. A wide acting family of Wnt mediators, secreted frizzled-related proteins (sFRPs), has not been probed so far as molecular indicators of disease occurrence and progression of Alzheimer's. Unlike the effect of the Dickkopf (DKK) family of Wnt antagonists on AD, the sFRP molecules have a more pleiotropic impact on the Wnt signaling cascade and probably have a far-reaching involvement in neurodegeneration. The role of sFRPs has been poorly described in AD, and in this review, we analyze the present status of the role of sFRPs on neurodegeneration, their likely involvement, and potential implications in treatment modalities of AD. This information would provide valuable clues for the development of potential therapeutic targets for aberrant neurodegenerative disorders.

dc.publisherPergamon
dc.titleSFRP-mediated Wnt sequestration as a potential therapeutic target for Alzheimer's disease
dc.typeJournal Article
dcterms.source.volume75
dcterms.source.startPage104
dcterms.source.endPage111
dcterms.source.issn1357-2725
dcterms.source.titleInternational Journal of Biochemistry and Cell Biology
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusOpen access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record