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    The effects of probiotic bacteria on glycaemic control in overweight men and women: a randomised controlled trial

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    Access Status
    Open access
    Authors
    Ivey, K.
    Hodgson, J.
    Kerr, Deborah
    Lewis, J.
    Thompson, P.
    Prince, R.
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Ivey, K. and Hodgson, J. and Kerr, D. and Lewis, J. and Thompson, P. and Prince, R. 2014. The effects of probiotic bacteria on glycaemic control in overweight men and women: a randomised controlled trial. European Journal of Clinical Nutrition. 68: pp. 447-452.
    Source Title
    European Journal of Clinical Nutrition
    DOI
    10.1038/ejcn.2013.294
    ISSN
    0954-3007
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/30080
    Collection
    • Curtin Research Publications
    Abstract

    Background/Objectives: Evidence from animal and in vitro models suggest a role of probiotic bacteria in improving glycaemic control and delaying the onset of type 2 diabetes. However, the evidence from controlled trials in humans is limited. The objective was to determine if the probiotic bacteria L. acidophilus La5 and B. animalis subsp lactis Bb12, supplemented in a whole food (yoghurt) or isolated (capsules) form, can improve biomarkers of glycaemic control. Subjects/methods: Following a 3-week washout period, 156 overweight men and women over 55 years (mean age: 67±8 years; mean body mass index (31±4 kg/m2) were randomized to a 6-week double-blinded parallel study. The four intervention groups were: (A) probiotic yoghurt plus probiotic capsules; (B) probiotic yoghurt plus placebo capsules; (C) control milk plus probiotic capsules; and (D) control milk plus placebo capsules. Outcome measurements, including fasting glucose, insulin, glycated haemoglobin and Homoeostasis Model Assessment of Insulin Resistance (HOMA-IR), were performed at baseline and week 6. Results: Relative to the milk-control group, probiotic yoghurt resulted in a significantly higher HOMA-IR (0.32±0.15, P=0.038), but did not have a significant effect on the other three measures of glycaemic control (P>0.05). Relative to placebo capsules, probiotic capsules resulted in a significantly higher fasting glucose (0.15±0.07 mmol/l, P=0.037), with no significant effect on the other three measures of glycaemic control (P>0.05). Further analyses did not identify other variables as contributing to these adverse findings. Conclusions: Data from this study does not support the hypothesis that L. acidophilus La5 and B. animalis subsp lactis Bb12, either in isolated form or as part of a whole food, benefit short-term glycaemic control. Indeed, there is weak data for an adverse effect of these strains on glucose homoeostasis.

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