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    Low serum 25-hydroxyvitamin D concentrations are associated with non-alcoholic fatty liver disease in adolescents independent of adiposity

    200160_200160.pdf (447.1Kb)
    Access Status
    Open access
    Authors
    Black, Lucinda
    Jacoby, P.
    Ping-Delfos, Wendy
    Mori, T.
    Beilin, L.
    Olynyk, John
    Ayonrinde, O.
    Huang, R.
    Holt, P.
    Hart, P.
    Oddy, W.
    Adams, L.
    Date
    2014
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Black, L. and Jacoby, P. and Ping-Delfos, W. and Mori, T. and Beilin, L. and Olynyk, J. and Ayonrinde, O. et al. 2014. Low serum 25-hydroxyvitamin D concentrations are associated with non-alcoholic fatty liver disease in adolescents independent of adiposity. Journal of Gastroenterology and Hepatology. 29 (6): pp. 1215-1222.
    Source Title
    Journal of Gastroenterology and Hepatology
    DOI
    10.1111/jgh.12541
    ISSN
    0815-9319
    School
    Health Sciences-Faculty Office
    Remarks

    This is the accepted version of the following article: Black, L. and Jacoby, P. and Ping-Delfos, W. and Mori, T. and Beilin, L. and Olynyk, J. and Ayonrinde, O. et al. 2014. Low serum 25-hydroxyvitamin D concentrations are associated with non-alcoholic fatty liver disease in adolescents independent of adiposity. Journal of Gastroenterology and Hepatology. 29 (6): pp. 1215-1222, which has been published in final form at http://doi.org/10.1111/jgh.12541

    URI
    http://hdl.handle.net/20.500.11937/3020
    Collection
    • Curtin Research Publications
    Abstract

    Background and Aims: Non-alcoholic fatty liver disease (NAFLD) and serum 25-hydroxyvitamin D (s25[OH]D) concentrations are both associated with adiposity and insulin resistance (IR) and thus may be pathogenically linked. We aimed to determine the prevalence of vitamin D deficiency in adolescents with NAFLD and to investigate the prospective and cross-sectional associations between s25[OH]D concentrations and NAFLD. Methods: Participants in the population-based West Australian Pregnancy (Raine) Cohort had seasonally adjusted s25(OH)D concentrations determined at ages 14 and then 17 years. NAFLD was diagnosed at 17 years using liver ultrasonography. Associations were examined after adjusting for potential confounders. Odds ratios (ORs) and confidence intervals (CIs) are reported per standard deviation in s25(OH)D concentrations. Results: NAFLD was present in 16% (156/994) of adolescents. The majority of participants with NAFLD had either insufficient (51%) or deficient (17%) vitamin D status. s25(OH)D concentrations at 17 years were inversely associated with risk of NAFLD (OR 0.74, 95% CI 0.56, 0.97; P = 0.029), after adjusting for sex, race, physical activity, television/computer viewing, body mass index, and IR. The effect of s25(OH)D concentrations at 17 years was minimally affected after further adjusting for s25(OH)D concentrations at 14 years (OR 0.76, 95% CI 0.56, 1.03; P = 0.072). Conclusions: Lower s25(OH)D concentrations are significantly associated with NAFLD, independent of adiposity and IR. Screening for vitamin D deficiency in adolescents at risk of NAFLD is appropriate, and clinical trials investigating the effect of vitamin D supplementation in the prevention and treatment of NAFLD may be warranted.

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