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TNF block haplotypes associated with conserved MHC haplotypes in European, Asian and Australian Aboriginal donors

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Authors
Valente, F.
Tan, C.
Phipps, M.
Witt, C.
Kaur, G.
Gut, I.
Allcock, R.
Price, Patricia
Date
2009
Type
Journal Article

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Valente, F. and Tan, C. and Phipps, M. and Witt, C. and Kaur, G. and Gut, I. and Allcock, R. et al. 2009. TNF block haplotypes associated with conserved MHC haplotypes in European, Asian and Australian Aboriginal donors. Tissue Antigens. 74 (1): pp. 57-61.
Source Title
Tissue Antigens
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School of Biomedical Sciences
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Abstract

Associations between major histocompatibility complex (MHC) ancestral haplotypes (AHs) and immunopathological diseases are traditionally ascribed to human leukocyte antigen (HLA) class I or class II alleles. However, polymorphisms in TNF and nearby genes in the central MHC can influence risk. We have defined TNF block haplotypes in Asian, European and Australian Aboriginal donors and shown conservation of TNF block haplotypes in geographically distinct populations, consistent with a common evolutionary origin. Here we show that most TNF block haplotypes do not align with a single MHC AH and associations often vary with ethnicity. This suggests more recent recombination events between the TNF block and the HLA alleles. © 2009 John Wiley & Sons A/S.