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    Gene expression profile of vascular ischemia-reperfusion injury in rhesus monkeys

    Access Status
    Fulltext not available
    Authors
    Luo, R.
    Li, L.
    Du, X.
    Shi, M.
    Zhou, C.
    Wang, C.
    Liao, G.
    Lu, Y.
    Zhong, Z.
    Cheng, J.
    Chen, Younan
    Date
    2015
    Type
    Journal Article
    
    Metadata
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    Citation
    Luo, R. and Li, L. and Du, X. and Shi, M. and Zhou, C. and Wang, C. and Liao, G. et al. 2015. Gene expression profile of vascular ischemia-reperfusion injury in rhesus monkeys. Gene.
    Source Title
    Gene
    DOI
    10.1016/j.gene.2015.10.073
    ISSN
    0378-1119
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/30375
    Collection
    • Curtin Research Publications
    Abstract

    © 2015. The vascular system particularly endothelium is sensitive to ischemia-reperfusion (I/R) injury, which is a big challenge in surgical practices and many vascular disorders. In the present study, we reported the global gene expression changes in a 2-h ischemia and 4-h reperfusion injury induced in the hind limb vessels of rhesus monkeys (Macaca mulatta) using microarray technique. Results: The histological results showed abnormal morphology of endothelial cells after 2-h ischemia and the hematological detection found slightly extension of coagulation time after I/R treatment. Furthermore, we found distinct alterations in gene expression patterns during I/R process. These identified genes are mostly involved in inflammation, immune response, apoptosis, and cell stress signaling pathways. The significantly up-regulated genes included IL-6, regulator of G-protein signaling 8, selectin E, and metallothionein 2A, et al. Whist, the robustly down-regulated genes included NECAP endocytosis associated 2, transglutaminase 2, and fibronectin 1, et al. Conclusion: Our results indicate that inflammation, primarily characterized by gene expression changes of cytokines and chemokines is the most important event in the early stage of I/R injury in blood vessels.

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