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    Probiotics as a Promising Treatment for Inflammatory Bowel Disease

    Access Status
    Fulltext not available
    Authors
    Mikov, Momir
    Stojancevic, M.
    Bojic, G.
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Mikov, M. and Stojancevic, M. and Bojic, G. 2014. Probiotics as a Promising Treatment for Inflammatory Bowel Disease. Hospital Pharmacology. 1 (1): pp. 52-60.
    Source Title
    Hospital Pharmacology
    Additional URLs
    http://www.hophonline.org/wp-content/uploads/2014/05/052-060-HoPh-Vol1-No1.pdf
    ISSN
    2334-9492
    School
    School of Pharmacy
    URI
    http://hdl.handle.net/20.500.11937/30383
    Collection
    • Curtin Research Publications
    Abstract

    Treatment of chronic inflammatory gastrointestinal conditions such as inflammatory bowel disease (IBD) is difficult due to the ambiguity surrounding their precise etiology. Complex interaction of genetic, microbial and environmental factors leads to sustained activation of the mucosal immune system resulting in active inflammation. Despite the efficacy of conventional therapy, significant side effects can occur, highlighting the need for novel treatment approaches to IBD. Since gut microflora appears to play a significant role in IBD, manipulation of its composition and activity by administering beneficial bacteria - probiotics, has been identified as a potential therapeutic option. Probiotic bacteria are able to modify and improve the intestinal environment and subsequently reduce the severity of intestinal inflammation associated with IBD. Clinical evidence suggest that probiotics can maintain remission in Ulcerative colitis (UC) and Crohn’s disease (CD) but there are no convincing reports on the effectiveness in patients with more severe active forms of IBD. This review will explore various mechanisms how probiotics may affect IBD and summarize the current knowledge regarding the role of probiotics in IBD.

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