Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    The Molecular Epidemiology and Evolution of Murray Valley Encephalitis Virus: Recent Emergence of Distinct Sub-lineages of the Dominant Genotype 1

    235573.pdf (1.056Mb)
    Access Status
    Open access
    Authors
    Williams, D.
    Diviney, S.
    Niazi, A.
    Durr, P.
    Chua, Beng Hooi
    Herring, B.
    Pyke, A.
    Doggett, S.
    Johansen, C.
    Mackenzie, John
    Date
    2015
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Williams, D. and Diviney, S. and Niazi, A. and Durr, P. and Chua, B. and Herring, B. and Pyke, A. et al. 2015. The Molecular Epidemiology and Evolution of Murray Valley Encephalitis Virus: Recent Emergence of Distinct Sub-lineages of the Dominant Genotype 1. PLoS Neglected Tropical Diseases. 9 (11): e0004240.
    Source Title
    PLoS Neglected Tropical Diseases
    DOI
    10.1371/journal.pntd.0004240
    ISSN
    1935-2727
    Faculty
    Faculty of Health Sciences
    Remarks

    This open access article is distributed under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

    URI
    http://hdl.handle.net/20.500.11937/30409
    Collection
    • Curtin Research Publications
    Abstract

    © 2015 Williams et al. Background: Recent increased activity of the mosquito-borne Murray Valley encephalitis virus (MVEV) in Australia has renewed concerns regarding its potential to spread and cause disease. Methodology/Principal Findings: To better understand the genetic relationships between earlier and more recent circulating strains, patterns of virus movement, as well as the molecular basis of MVEV evolution, complete pre-membrane (prM) and Envelope (Env) genes were sequenced from sixty-six MVEV strains from different regions of the Australasian region, isolated over a sixty year period (1951–2011). Phylogenetic analyses indicated that, of the four recognized genotypes, only G1 and G2 are contemporary. G1 viruses were dominant over the sampling period and found across the known geographic range of MVEV. Two distinct sub-lineages of G1 were observed (1A and 1B). Although G1B strains have been isolated from across mainland Australia, Australian G1A strains have not been detected outside northwest Australia. Similarly, G2 is comprised of only Western Australian isolates from mosquitoes, suggesting G1B and G2 viruses have geographic or ecological restrictions. No evidence of recombination was found and a single amino acid substitution in the Env protein (S332G) was found to be under positive selection, while several others were found to be under directional evolution. Evolutionary analyses indicated that extant genotypes of MVEV began to diverge from a common ancestor approximately 200 years ago. G2 was the first genotype to diverge, followed by G3 and G4, and finally G1, from which subtypes G1A and G1B diverged between 1964 and 1994. Conclusions/Significance: The results of this study provides new insights into the genetic diversity and evolution of MVEV. The demonstration of co-circulation of all contemporary genetic lineages of MVEV in northwestern Australia, supports the contention that this region is the enzootic focus for this virus.

    Related items

    Showing items related by title, author, creator and subject.

    • Widespread transmission of distinct genetic lineages of Murray Valley encephalitis virus in Australia, 2008-2009
      Williams, David; Diviney, Sinead; Niazi, A.; Herring, B.; Johansen, C.; MacKenzie, John (2011)
      Murray valley encephalitis virus (MVEV) is the most important cause of arboviral neurological disease in humans in Australia. Increased activity of MVEV was observed in Australia in 2008 and 2009, leading to fatal human ...
    • Widespread transmission of distinct genetic lineages of Murray Valley encephalitis virus in Australia, 2008-2009
      Williams, David; Diviney, Sinead; Niazi, A.; Herring, B.; Johansen, C.; MacKenzie, John (2011)
      Increased activity of the mosquito-borne Murray valley encephalitis virus (MVEV) was observed in Australia in 2008 and 2009, leading to fatal human and equine cases, and renewed concerns regarding its potential to spread ...
    • Molecular Characterisation of Murray Valley Encephalitis Virus
      Diviney, Sinead; Williams, David; Geerlings, K.; Chua, B.; Yu, M.; Hansson, E.; Wang, L.; MacKenzie, John (2007)
      Murray Valley encephalitis viru's (MVEV) is an encephalitogenic mosquito-borne flavivirus endemic to Australia and Papua New Guinea (PNG). Four genotypes (GI-IV) of MVEV have been previously recognised: GI and GIl circulate ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.