Pharmaceutical protein production by yeast: Towards production of human blood proteins by microbial fermentation
MetadataShow full item record
Since the approval of recombinant insulin from Escherichia coli for its clinical use in the early 1980s, the amount of recombinant pharmaceutical proteins obtained by microbial fermentations has significantly increased. The recent advances in genomics together with high throughput analysis techniques (the so-called - omics approaches) and integrative approaches (systems biology) allow the development of novel microbial cell factories as valuable platforms for large scale production of therapeutic proteins. This review summarizes the main achievements and the current situation in the field of recombinant therapeutics using yeast Saccharomyces cerevisiae as a model platform, and discusses the future potential of this platform for production of blood proteins and substitutes. © 2012 Elsevier Ltd.
Showing items related by title, author, creator and subject.
Chang, Elizabeth; Sidhu, Amandeep; Sidhu, B.; Dillon, Tharam S. (2005)The rapid generation of accessible protein data sources has generated confusion over protein data representation. The protein ontology project seeks to provide a set of structured vocabularies for protein domains that can ...
Berwick, Lyndon (2009)The analytical capacity of MSSV pyrolysis has been used to extend the structural characterisation of aquatic natural organic matter (NOM). NOM can contribute to various potable water issues and is present in high ...
Effect of dietary protein and lipid source on the growth, survival, condition indices, and body composition of marron, Cherax tenuimanus (Smith)Fotedar, Ravi (2004)A trial was conducted in 12 purpose-built, commercial, drainable, earthen ponds to evaluate the effect of fish and plant protein and lipid source on the growth, condition indices, and body composition of marron (Cherax ...