Pharmaceutical protein production by yeast: Towards production of human blood proteins by microbial fermentation

Martínez, J.; Liu, Lifang; Petranovic, D.; Nielsen, J.

doi:10.1016/j.copbio.2012.03.011

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Authors

Martínez, J.

Liu, Lifang

Petranovic, D.

Nielsen, J.

Date

2012

Type

Journal Article

Metadata

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Citation

Martínez, J. and Liu, L. and Petranovic, D. and Nielsen, J. 2012. Pharmaceutical protein production by yeast: Towards production of human blood proteins by microbial fermentation. Current Opinion in Biotechnology. 23 (6): pp. 965-971.

Source Title

Current Opinion in Biotechnology

DOI

10.1016/j.copbio.2012.03.011

ISSN

0958-1669

School

Centre for Crop Disease Management

URI

http://hdl.handle.net/20.500.11937/30466

Collection

Curtin Research Publications

Abstract

Since the approval of recombinant insulin from Escherichia coli for its clinical use in the early 1980s, the amount of recombinant pharmaceutical proteins obtained by microbial fermentations has significantly increased. The recent advances in genomics together with high throughput analysis techniques (the so-called - omics approaches) and integrative approaches (systems biology) allow the development of novel microbial cell factories as valuable platforms for large scale production of therapeutic proteins. This review summarizes the main achievements and the current situation in the field of recombinant therapeutics using yeast Saccharomyces cerevisiae as a model platform, and discusses the future potential of this platform for production of blood proteins and substitutes. © 2012 Elsevier Ltd.