Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Genetic architecture of carotid artery intima-media thickness in Mexican Americans

    Access Status
    Open access via publisher
    Authors
    Melton, P.
    Carless, M.
    Curran, J.
    Dyer, T.
    Göring, H.
    Kent, J.
    Drigalenko, E.
    Johnson, M.
    MacCluer, J.
    Moses, Eric
    Comuzzie, A.
    Mahaney, M.
    O'Leary, D.
    Blangero, J.
    Almasy, L.
    Date
    2013
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Melton, P. and Carless, M. and Curran, J. and Dyer, T. and Göring, H. and Kent, J. and Drigalenko, E. et al. 2013. Genetic architecture of carotid artery intima-media thickness in Mexican Americans. Circulation: Cardiovascular Genetics. 6 (2): pp. 211-221.
    Source Title
    Circulation: Cardiovascular Genetics
    DOI
    10.1161/CIRCGENETICS.113.000079
    ISSN
    1942-325X
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/30820
    Collection
    • Curtin Research Publications
    Abstract

    Background: Intima-media thickness (IMT) of the common and internal carotid arteries is an established surrogate for atherosclerosis and predicts risk of stroke and myocardial infarction. Often IMT is measured as the average of these 2 arteries; yet, they are believed to result from separate biological mechanisms. The aim of this study was to conduct a family-based genome-wide association study (GWAS) for IMT to identify polymorphisms influencing IMT and to determine if distinct carotid artery segments are influenced by different genetic components. Methods and Results: IMT for the common and internal carotid arteries was determined through B-mode ultrasound in 772 Mexican Americans from the San Antonio Family Heart Study. A GWAS using 931219 single-nucleotide polymorphisms was undertaken with 6 internal and common carotid artery IMT phenotypes using an additive measured genotype model. The most robust association detected was for 2 single-nucleotide polymorphisms (rs16983261, rs6113474; P=1.60e−7) in complete linkage disequilibrium on chromosome 20p11 for the internal carotid artery near wall, next to the gene PAX1. We also replicated previously reported GWAS regions on chromosomes 19q13 and 7q22. We found no overlapping associations between internal and common carotid artery phenotypes at P<5.0e−6. The genetic correlation between the 2 carotid IMT arterial segments was 0.51. Conclusions: This study represents the first large-scale GWAS of carotid IMT in a non–European population and identified several novel loci. We do not detect any shared GWAS signals between common and internal carotid arterial segments, but the moderate genetic correlation implies both common and unique genetic components.

    Related items

    Showing items related by title, author, creator and subject.

    • Length of carotid stenosis predicts peri-procedural stroke or death and restenosis in patients randomized to endovascular treatment or endarterectomy
      Bonati, L.; Ederle, J.; Dobson, J.; Engelter, S.; Featherstone, R.; Gaines, P.; Beard, J.; Venables, G.; Markus, H.; Clifton, A.; Sandercock, P.; Brown, M.; Bland, J.; Brown, M.; Buckenham, T.; Clifton, A.; Sandercock, P.; Taylor, R.; Tognoni, G.; Warlow, C.; Bleakley, T.; Colquhoun, D.; Coward, L.; Crawley, F.; Dobinson, P.; Featherstone, R.; Holder, S.; Markus, H.; McCabe, D.; Pereira, A.; Rogers, J.; Silver, L.; Burrett, J.; Crowther, J.; Dobson, M.; Hafner, B.; Heineman, J.; Hope, C.; Knight, S.; Naughten, A.; Radley, A.; Richards, S.; Smith, D.; Wenzel, S.; Harrison, M.; Ferro, J.; Beard, J.; Buckenham, T.; Brown, M.; Clifton, A.; Bladin, C.; Donnan, G.; Fell, G.; Fitt, G.; Royle, J.; Davis, S.; Gerraty, R.; Mitchell, P.; Goodman, M.; Hankey, G.; Khangure, M.; Lawrence-Brown, Michael; Linto, J.; McAuliffe, W.; Prendergast, F.; Siennarine, K.; Stewart-Wynne, E.; Grahovac, S.; Morrish, W.; Pageau, N.; E Pringle, C.; Richard, D.; Malms, J.; Reiher, L.; Siebler, M.; Belloni, G.; Porta, M.; Chamorro, A.; Vila, N.; Riambau, V.; Vazquez, F.; Boza, F.; Garcia Rodríguez, J.; Gil Peralta, A.; González, A.; González Marcos, J.; Mayol Deya, A.; Rauno, J.; Kirsch, E.; Lyrer, P.; Rem, J.; Bogousslavsky, J.; Uske, A.; Beard, J.; Cleveland, T.; Doyle, C.; Gaines, P.; Sivaguru, A.; Venables, G.; Brown, M.; Buckenham, T.; Clifton, A.; Colquhoun, D.; Crawley, F.; Leopold, P.; Loosemore, T.; McCabe, D.; Pereira, A.; Rogers, J.; Taylor, R.; Enevoldson, T.; Gilling-Smith, G.; Harris, P.; Nixon, T.; Baskerville, P.; Cox, T.; Fraser, S.; Jeffrey, M.; Markus, H.; Molloy, J.; Butler, P.; Dick, J.; Frankel, F.; Bradbury, A.; Collie, D.; Murie, J.; Ruckley, C.; Sandercock, P.; Schultz, D.; Sellar, R.; Wardlaw, J.; Ashleigh, R.; McCollum, C.; O'Neill, P.; Gholkar, A.; Mendelow, A.; Walls, T.; Angus-Leppan, H.; Halpin, S.; Hughes, J.; Lane, I.; Wiles, M.; Wood, A.; Birch, P.; Earnshaw, J.; Fuller, G.; Heather, B.; Poskitt, K.; Tottle, A.; Hope, D.; Jefferson, D.; McConachie, N.; Duddy, M.; Heafield, M.; Vohra, R. (2014)
      Background: The anatomy of carotid stenosis may influence the outcome of endovascular treatment or carotid endarterectomy. Whether anatomy favors one treatment over the other in terms of safety or efficacy has not been ...
    • Genetic overlap analysis of endometriosis and asthma identifies shared loci implicating sex hormones and thyroid signalling pathways
      Adewuyi, Emmanuel ; Mehta, D.; Nyholt, D.R. (2022)
      STUDY QUESTION: Is there a shared genetic or causal association of endometriosis with asthma or what biological mechanisms may underlie their potential relationships? SUMMARY ANSWER: Our results confirm a significant but ...
    • Circulating CD14+ and CD14highCD16− classical monocytes are reduced in patients with signs of plaque neovascularization in the carotid artery
      Ammirati, E.; Moroni, F.; Magnoni, M.; Di Terlizzi, S.; Villa, C.; Sizzano, F.; Palini, A.; Garlaschelli, K.; Tripiciano, F.; Scotti, I.; Catapano, A.; Manfredi, A.; Norata, Giuseppe; Camici, P. (2016)
      Background and aims: Monocytes are known to play a key role in the initiation and progression of atherosclerosis and contribute to plaque destabilization through the generation of signals that promote inflammation and ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.